The synthetic heterocyclic compounds have their importance due to their wide applications in various
fields of science. The heterocyclic compounds have been reported for their anticancer, antitubercular, insecticides,
analeptics, analgesic, anti-bacterial, anti-viral, anti-fungal, and weedicidal activity. Researchers have tried various
newer targets in search of better antimicrobials acting via novel mechanisms. Glucosamine-6-Phosphate synthase
is an enzyme present in microbial cells. The inactivation of G-6-P synthase may serve as a novel approach to find
better antimicrobials. The increasing demands development of newer and effective antimicrobial drugs has reported
in search of newer techniques for the generation of new drugs. Hence, the molecular docking technique
shall be explored to find or investigate the newer target finding the novel compounds which can be an active
antimicrobial compound. The present review has focused on the reported heterocyclic compounds which have
been evaluated for their antimicrobial potential using G-6-P synthase as a target. The results of in silico methods
and in vitro methods have been compared and critically discussed.
Keywords: Antimicrobial, G-6-P synthase, heterocyclic, in silico, antitubercular, anticancer, microbial cells.
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