Recently small noncoding microRNAs (miRNAs) are known as noninvasive biomarkers for early detection in various cancers. In fact, miRNAs have key roles in carcinogenicity process such as out of proliferation, block of apoptosis and metastasis. After cardiovascular disease, cancer is the second cause of death in the world which is estimated that around 9.6 million people death in 2018. So, early diagnosis of cancer is critical for their successful treatment. To date, several selective and sensitive laboratory-based methods have been applied for detection of circulating miRNA, but a simple, short assay time and low-cost method such as a biosensor method as an alternative approach to monitor the cancer’s biomarker is required. In this view, we have highlighted the recent advances biosensors for circulating miRNA detection.