Voltage-gated Sodium Channels in Sensory Information Processing

Author(s): You Zhou , Ping Pan , Zhi-Yong Tan , Yong-Hua Ji* .

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 18 , Issue 4 , 2019

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Abstract:

Objective & Background: Voltage-gated sodium channels (VGSCs) and potassium channels are critical in the generation of action potentials in the nervous system. VGSCs and potassium channels play important roles in the five fundamental senses of vision, audition, olfaction, taste and touch. Dysfunctional VGSCs are associated with clinical sensory symptoms, such as hyperpselaphesia, parosphresia, and so on.

Conclusion: This short review highlights the recent advances in the study of VGSCs in sensory information processing and discusses the potential role of VGSCs to serve as pharmacological targets for the treatment of sensory system diseases.

Keywords: Voltage-gated sodium channel, action potential, information processing, membrane, protein complexes central nervous system, pharmacological.

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Article Details

VOLUME: 18
ISSUE: 4
Year: 2019
Page: [273 - 278]
Pages: 6
DOI: 10.2174/1871527317666180627114849
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