Aging is a complex phenomenon, where damage accumulation, increasing deregulation of
biological pathways, and loss of cellular homeostasis lead to the decline of organismal functions over
time. Interestingly, aging is not entirely a stochastic process and progressing at a constant rate, but it is
subject to extensive regulation, in the hands of an elaborate and highly interconnected signaling network.
This network can integrate a variety of aging-regulatory stimuli, i.e. fertility, nutrient availability,
or diverse stresses, and relay them via signaling cascades into gene regulatory events - mostly of
genes that confer stress resistance and thus help protect from damage accumulation and homeostasis
loss. Transcription factors have long been perceived as the pivotal nodes in this network. Yet, it is well
known that the epigenome substantially influences eukaryotic gene regulation, too. A growing body of
work has recently underscored the importance of the epigenome also during aging, where it not only
undergoes drastic age-dependent changes but also actively influences the aging process. In this review,
we introduce the major signaling pathways that regulate age-related decline and discuss the synergy
between transcriptional regulation and the epigenetic landscape.