Background: The discovery of new chemotherapeutic agents still remains a continuous
goal to achieve. DNA polymerases and topoisomerases act in nucleic acids metabolism modulating
different processes like replication, mitosis, damage repair, DNA topology and transcription. It has
been widely documented that Polymerases serve as molecular targets for antiviral and antitumoral
chemotherapy. Furthermore, telomerase is a ribonucleoprotein with exacerbated activity in most of the
tumor cell lines, becoming as an emergent target in Cancer treatment.
Methods: We undertook an exhaustive search of bibliographic databases for peer-reviewed research
literature related to the last decade. The characteristics of screened bibliography describe structure activity
relationships and show the principal moieties involved. This work tries to summarize the investigation
about natural and semi-synthetic products with natural origin with the faculty to inhibit key
enzymes that play a crucial role in DNA metabolism.
Results: Eighty-five data references were included in this review, showing natural products widely
distributed throughout the plant kingdom and their bioactive properties such as tumor growing inhibitory
effects, and anti-AIDS activity.
Conclusion: The findings of this review confirm the importance to find new drugs and biologically
active natural products, and their potential medicinally useful benefits.