Background: Epileptic children and adolescent have a significantly low serum level of
vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are
at risk of cardiovascular events.
Objective: This study aimed to show that epileptic patients who treated with antiepileptic drugs
supplemented with vitamin D are free from the electrocardiograph changes compared with those
treated with antiepileptic drugs.
Method: This cross-sectional study included, 121 epileptic patients aged < 18 years of both genders
with a history of idiopathic generalized tonic clonic seizure. They grouped into Group I (n=20)
patients without medical treatment, Group II (n=76) patients treated with antiepileptic drugs, and
vitamin D Group III (n=25) patients treated with antiepileptic drugs supplemented with vitamin D3
vitamin D. Each participant subjected to the electrocardiogram investigation at the time of entry
into the study.
Results: Group III patients had a significant decrease of QRS complex, QRS dispersion QTcorrected,
and TQ duration compared with Group II. Group I patients, had a significant increase of
QRS complex duration, compared with Group II patients. Four patients of Group II showed a significant
prolonged QT-interval in the QT nomogram. Three patients had a JT index (an indicator of
ventricular hyperpolarization) more than the normal cutoff level of 112. The area under the curve of
receiving operating characteristics showed significant favorable effects of vitamin D supplementation
on the different variables of electrocardiograph.
Conclusion: Vitamin D supplementation may correct the changes in the electrocardiograph observed
in idiopathic generalized tonic clonic seizure treated with antiepileptic medicines, and our
observations warrant larger studies.