Background: The effects of various chemotherapeutic agents have been assessed for their
capacity to inhibit the cell replication in variety of cancer cases. At present there are more than hundred
chemotherapeutic agents capturing worth 42 billion dollar of drug market. The major obstacle in the
successful treatment of cancer is the obnoxious side effects of chemotherapeutics and multi drug resistance,
which deteriorates the quality of life of cancer patient.
Objective: This article attempts to summarize different novel chemotherapeutic delivery systems which
aim to circumvent these unwanted effects.
Areas Covered: Outcomes of different tumor directed carrier systems have been discussed with special
emphasis on nanocarriers systems, drug polymer conjugation, directly implantable matrices and others.
In addition, combination therapy and immunotherapy are also discussed as a revolutionary alternative.
Conclusion: Even though significant contributions have been made in the development of carrier systems
for the chemotherapeutic agents, merits and demerits of all the avenues should be critically examined.
Potential of all novel strategies should be exploited by critically evaluating their strength, weakness,
opportunities and threats. Further, clinical trials based on revised and critically scrutinized frameworks
and protocols are needed so that the efficiency and safe action of these new systems can be guaranteed
in cancer patients.