Current Neurovascular Research

Prof. Kenneth Maiese
Neurology and Neurosciences UMDNJ
205 South Orange Avenue, F1220
Newark, NJ 07101
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Neuroinflammation: Microglial Activation During Sepsis

Author(s): Monique Michels, Lucineia G. Danielski, Felipe Dal-Pizzol and Fabricia Petronilho

Affiliation: Programa de Pos Graduacao em Ciencias da Saude, Universidade do Sul de Santa Catarina, Tubarao, SC, Brazil, Avenida Jose Acacio Moreira, 787, 88704-900.

Keywords: Blood-brain barrier, CNS, encephalopathy, microglia, neuroinflammation, sepsis.

Abstract:

Neuroinflammation is presented in the acute phase brain damage as well as chronic diseases. Cells that are directly or indirectly involved in immune responses compose the central nervous system (CNS). Microglia are resident cells of the CNS and, as peripheral macrophages, are activated in presence of some cellular insult, producing a large number of cytokines and chemokines in order to remove toxins from the extracellular space. This activation can lead to a breakdown of the blood-brain barrier, production of reactive oxygen species that is involved in the progression of CNS damage as occurs in septic encephalopathy. Given the growing relevance of microglia in the area of neurotoxicology, we describe the role of microglia and the cellular mechanisms that activate these cells during sepsis. Thus, in this review we focused on the relationship between microglia and neuroinflammation associated with sepsis.

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Article Details

VOLUME: 11
ISSUE: 3
Page: [262 - 270]
Pages: 9
DOI: 10.2174/1567202611666140520122744