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Current Neurovascular Research


ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

Author(s): Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu Krishnamurthy

Volume 11, Issue 3, 2014

Page: [271 - 278] Pages: 8

DOI: 10.2174/1567202611666140520151002

Price: $65


Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.

Keywords: Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.

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