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Current Hypertension Reviews
ISSN (Print): 1573-4021
ISSN (Online): 1875-6506
VOLUME: 9
ISSUE: 3
DOI: 10.2174/1573402110666140131161338









Vasospastic Angina and Ca Channel Blockers

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Author(s): Shinya Minatoguchi
Pages 219-223 (5)
Abstract:
Coronary artery spasm is one of the causes of angina pectoris,acute myocardial infarction and ventricular fibrillation-related sudden death. It has been established that Ca channel blockers are protective against vasospastic angina (VSA) and treatment with Ca channel blockers provides a better prognosis of VSA. However, it is not still clarified what kinds of Ca channel blockers shows the best prognosis of VSA. We performed a meta-analysis in which 4Ca channel blockers amlodipine, nifedipine, benidipine and diltiazem were used for the treatment of VSA patients and found that among 4 Ca channel blockers, benidipine showed a statistically significant better prognostic effect on MACE than amlodipine, nifedipine or diltiazem.
Keywords:
Ca channel blocker, cardiovascular event, vasospastic angina.
Affiliation:
Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1-1, Gifu, Gifu 501-1194, Japan.