Human Growth Hormone Induced Cholestatic Hepatitis in a Growth Hormone Deficient Patient with Short Stature
Mozhghan Zahmatkeshan, Zohre Karamizadeh, Bita Geramizadeh and Ahad Eshraghian
Affiliation: Department of Internal Medicine, Namazi hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Case Description: We report a patient with growth hormone deficiency that developed cholestatic hepatitis
during treatment with recombinant human growth hormone (HGH). The patient developed jaundice and pruritus during
treatment with growth hormone. She did not use any other medications. Her jaundice and pruritus were disappeared and
liver enzyme disturbances were normalized after HGH discontinuation.
Conclusion: Clinician should be aware of this potential adverse drug reaction and frequent checking of liver enzymes is
recommended in patients treating with HGH.
Keywords: Cholestatic hepatitis, human growth hormone, growth hormone deficiency.
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