Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of
enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc
metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer’s disease. Recent studies provide
inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards
treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn
between IDE, Type 2 Diabetes mellitus and Alzheimer’s disease and the approaches that make IDE a potential target, are
Keywords: Insulin degrading enzyme, Alzheimer’s disease, Type 2 Diabetes mellitus, Caenorhabditis elegans.
Rights & PermissionsPrintExport