Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain

Author(s): Jialie Luo, Edgar T Walters, Susan M Carlton, Hongzhen Hu.

Journal Name: Current Neuropharmacology

Volume 11 , Issue 6 , 2013

Abstract:

Chronic pain affects billions of lives globally and is a major public health problem in the United States. However, pain management is still a challenging task due to a lack of understanding of the fundamental mechanisms of pain. In the past decades transient receptor potential (TRP) channels have been identified as molecular sensors of tissue damage and inflammation. Activation/sensitization of TRP channels in peripheral nociceptors produces neurogenic inflammation and contributes to both somatic and visceral pain. Pharmacological and genetic studies have affirmed the role of TRP channels in multiple forms of inflammatory and neuropathic pain. Thus pain-evoking TRP channels emerge as promising therapeutic targets for a wide variety of pain and inflammatory conditions.

Keywords: Transient receptor potential channels, pain, inflammation, neuropathy, pain management, drug target.

Rights & PermissionsPrintExport

Article Details

VOLUME: 11
ISSUE: 6
Year: 2013
Page: [652 - 663]
Pages: 12
DOI: 10.2174/1570159X113119990040
Price: $58

Article Metrics

PDF: 9
HTML: 0
EPUB: 0
PRC: 0