Levosimendan Preoperative

Author(s): Andrea Rognoni, Alessandro Lupi, Chiara Cavallino, Alessia Veia, Sara Bacchini, Roberta Rosso, Gioel Gabrio Secco, Angelo Sante Bongo.

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 22 , 2013

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Abstract:

During the last years an increasing number of patients with high perioperative risk and decreased left ventricular function are referred to cardiac and non-cardiac surgery. In this subgroup of patients, heart failure is the major cause of perioperative morbidity and mortality. In order to prevent and treat this type of complications several therapeutic attempts have been tried involving intra aortic balloon pump and inotropic agents infusion (such as beta-adrenergic agonists and phosphodiesterase inhibitors)

Levosimendan is new inotropic agent; it is a calcium-sensitising inotropic agent and a vasodilator used in the treatment of heart failure. In the last ten years several reports have been published on levosimendan. The inotropic efficacy of levosimendan is dose-dependent and equal or even superior to any of the other commercially available inotropic agents.

The aim of the present review is to describe experimental and clinical effects of perioperative treatment with levosimendan.

Keywords: Levosimendan, heart failure, cardiac surgery.

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Article Details

VOLUME: 19
ISSUE: 22
Year: 2013
Page: [3974 - 3978]
Pages: 5
DOI: 10.2174/1381612811319220005
Price: $58

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