Endocrine, Metabolic & Immune Disorders-Drug Targets

(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Emilio Jirillo  
Universitá degli Studi di Bari
Dipartimento di Clinica Medica
Immunologia e Malattie Infettive
Sezione di Microbiologia e Immunologia
Piazza Giulio Cesare-Policlinico


Thyroid Disorders in Chronic Heart Failure: From Prognostic Set-up to Therapeutic Management

Author(s): Vincenzo Triggiani and Massimo Iacoviello

Affiliation: Endocrinology and Metabolic Diseases, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro” School of Medicine, Policlinico, Bari, Italy.

Keywords: Chronic heart failure, prognosis, therapy, thyroid.


Thyroid hormones have relevant activity at cardiac and vascular level, by influencing heart rate, myocardial excitability as well as inotropic and lusitropic status, systemic vascular resistance and blood pressure. Moreover, they interact with neuro-hormonal systems such as sympathetic nervous system and renin-angiotensin-aldosterone system thus also indirectly influencing cardiovascular function. Due to these effects, both hypothyroidism and hyperthyroidism, either in their overt or subclinical forms, can have an unfavourable impact in the setting of cardiovascular diseases.

The aim of this review is to focus on the prognostic consequences of thyroid disorders in heart failure patients. Moreover, the therapeutical approach and the possible beneficial effects of restoring euthyroidism are reviewed.

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Article Details

Page: [22 - 37]
Pages: 16
DOI: 10.2174/1871530311313010005