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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)
ISSN (Print): 1871-5230
ISSN (Online): 1875-614X
VOLUME: 12
ISSUE: 1
DOI: 10.2174/1871523011312010005









Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models

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Author(s): Nolwenn Merlet, David Busseuil, Eric Rheaume and Jean-Claude Tardif
Pages 24-35 (12)
Abstract:
Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids, nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.
Keywords:
Glucocorticoids, NSAIDs, biologics, heart failure, ischemia/reperfusion, cardiac hypertrophy, cardiotoxic drugs, experimental models
Affiliation:
Montreal Heart Institute, Research Center, 5000 Bélanger Est, Montréal, QC, Canada (H1T 1C8).