Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models
Nolwenn Merlet, David Busseuil, Eric Rheaume and Jean-Claude Tardif
Affiliation: Montreal Heart Institute, Research Center, 5000 Bélanger Est, Montréal, QC, Canada (H1T 1C8).
Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary
heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been
shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids,
nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are
associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from
experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.
Keywords: Glucocorticoids, NSAIDs, biologics, heart failure, ischemia/reperfusion, cardiac hypertrophy, cardiotoxic drugs,
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