In Vivo Human X-ray Investigation of Combined Polysaccharide Based Drug Delivery Systems Prepared for Colonic Delivery
Sidramappa M. Chickpetty and Basawaraj V. Raga
Affiliation: Department of Pharmaceutics, K.R.E.S’s Karnataka College of Pharmacy, Bidar, Karnataka, India.
The present investigation was aimed to assess the in vivo performance of combined polysaccharides based
compression coated tablets for colonic delivery using X-ray study. Fast disintegrating core tablets containing barium sulphate
was compression coated with guar gum (GG), locust bean gum (LBG) and hydroxyl propyl methyl cellulose
(HPMC) in the ratio 3:3:4 with a coat weight of 400mg. The developed barium sulphate coated tablet was subjected for in
vivo human X-ray study. X-ray study revealed that the tablet remained intact during its transit through upper part of gastrointestinal
tract. The colon arrival time was found to be between 5-8 h. The disintegration of the tablet occurred in the
colon between 14 to 16 h by the microflora present in the colon. In conclusion, results of X-ray studies revealed that GG
and LBG along with HPMC was found to be promising coating materials for targeting drugs specifically to the colon.
Keywords: Colon specific drug delivery system, colon targeting, compression-coat, diclofenac sodium, guar gum, locust bean
gum, X-ray imaging and HPMC.
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