In Vivo Human X-ray Investigation of Combined Polysaccharide Based Drug Delivery Systems Prepared for Colonic Delivery
Sidramappa M. Chickpetty and Basawaraj V. Raga
Affiliation: Department of Pharmaceutics, K.R.E.S’s Karnataka College of Pharmacy, Bidar, Karnataka, India.
Keywords: Colon specific drug delivery system, colon targeting, compression-coat, diclofenac sodium, guar gum, locust bean
gum, X-ray imaging and HPMC.
The present investigation was aimed to assess the in vivo performance of combined polysaccharides based
compression coated tablets for colonic delivery using X-ray study. Fast disintegrating core tablets containing barium sulphate
was compression coated with guar gum (GG), locust bean gum (LBG) and hydroxyl propyl methyl cellulose
(HPMC) in the ratio 3:3:4 with a coat weight of 400mg. The developed barium sulphate coated tablet was subjected for in
vivo human X-ray study. X-ray study revealed that the tablet remained intact during its transit through upper part of gastrointestinal
tract. The colon arrival time was found to be between 5-8 h. The disintegration of the tablet occurred in the
colon between 14 to 16 h by the microflora present in the colon. In conclusion, results of X-ray studies revealed that GG
and LBG along with HPMC was found to be promising coating materials for targeting drugs specifically to the colon.
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