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The Evolution of Cytochrome P450 Enzymes as Biocatalysts in Drug Discovery and Development

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 18 Year: 2013 Page: 2254-2280
Author(s): Elizabeth M.J. Gillam,Martin A. Hayes

Comparison of P450 Enzymes Between Cynomolgus Monkeys and Humans: P450 Identities, Protein Contents, Kinetic Parameters, and Potential for Inhibitory Profiles

Journal: Current Drug Metabolism
Volume: 14 Issue: 2 Year: 2013 Page: 239-252
Author(s): Chie Emoto,Noriaki Yoda,Yasuhiro Uno,Kazuhide Iwasaki,Ken Umehara,Eiji Kashiyama,Hiroshi Yamazaki

Overview on Theoretical Studies Discriminating the Two-Oxidant Versus Two-State-Reactivity Models for Substrate Monoxygenation by Cytochrome P450 Enzymes

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 18 Year: 2013 Page: 2218-2232
Author(s): Sam P. de Visser,Cristina S. Porro,Matthew G. Quesne,Mala A. Sainna,Andrew W. Munro

In Silico Prediction of Cytochrome P450-Mediated Site of Metabolism (SOM)

Journal: Protein & Peptide Letters
Volume: 20 Issue: 3 Year: 2013 Page: 279-289
Author(s): Xian Liu,Qiancheng Shen,Jing Li,Shanshan Li,Cheng Luo,Weiliang Zhu,Xiaomin Luo,Mingyue Zheng,Hualiang Jiang

Generation, Validation, and Application of a P450 Homology Model

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 18 Year: 2013 Page: 2233-2240
Author(s): Benjamin C. Lewis,John O. Miners

Combining In Silico Protein Stability Calculations with Structure-Function Relationships to Explore the Effect of Polymorphic Variation on Cytochrome P450 Drug Metabolism

Journal: Current Drug Metabolism
Volume: 14 Issue: 7 Year: 2013 Page: 745-763
Author(s): Lauren Arendse,Tom L. Blundell,Jonathan Blackburn

The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma

Journal: Current Pharmaceutical Design
Volume: 19 Issue: 4 Year: 2013 Page: 7155-7166
Author(s): Hesham M. Korashy, Hatim M. Abuohashish, Zaid H. Maayah

Cytochrome P450 Bioreactors in the Pharmaceutical Industry: Challenges and Opportunities

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 12 Year: 2013 Page: 1470-1490
Author(s): Carlos A. Martinez,Sanjeewa G. Rupasinghe

CYP4 Enzymes As Potential Drug Targets: Focus on Enzyme Multiplicity, Inducers and Inhibitors, and Therapeutic Modulation of 20- Hydroxyeicosatetraenoic Acid (20-HETE) Synthase and Fatty Acid ω- Hydroxylase Activities

Journal: Current Topics in Medicinal Chemistry
Volume: 13 Issue: 12 Year: 2013 Page: 1429-1440
Author(s): Katheryne Z. Edson,Allan E. Rettie

Cytochrome P450 2C19 Polymorphism and Antiplatelet Therapy. Who Should Really be Genotyped?

Journal: Current Pharmaceutical Design
Volume: 19 Issue: 1 Year: 2013 Page: 2489-2495
Author(s): George Kassimis, Eleana F. Stavrou, Dimitrios Alexopoulos, Aglaia Athanassiadou

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