Search Result "hydrophobic pocket"


Research Article

Identification of Novel Structurally Diverse Anaplastic Lymphoma Kinase Inhibitors Based on Pharmacophore Modeling, Virtual Screening and Molecular Docking

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 19 Issue: 9 Year: 2016 Page: 691-704
Author(s): Rong You,Lu Zhou,Liangliang Zhong,Xiaoli Li,Suwen Zhou,Yahui Tian

6,7-Dihydroxyisoindolin-1-one and 7,8-Dihydroxy-3,4-Dihydroisoquinolin- 1(2H)-one Based HIV-1 Integrase Inhibitors

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 4 Year: 2016 Page: 435-440
Author(s): Xue Zhi Zhao,Mathieu Métifiot,Steven J. Smith,Kasthuraiah Maddali,Christophe Marchand,Stephen H. Hughes,Yves Pommier,Terrence R. Burke, Jr.

Molecular Gymnastics: Mechanisms of HIV-1 Resistance to CCR5 Antagonists and Impact on Virus Phenotypes

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 1 Year: 2016 Page: 1091-1106
Author(s): Michael Roche, Katharina Borm, Jacqueline K. Flynn, Sharon R. Lewin, Melissa J. Churchill, Paul R. Gorry

Furocoumarins from Cnidium monnieri Act as Peroxisome Proliferatoractivated R and Farnesoid X Receptor Agonists

Journal: Mini-Reviews in Organic Chemistry
Volume: 13 Issue: 2 Year: 2016 Page: 88-96
Author(s): Hsiang-Ru Lin

Quantitative Structure-Activity Relationship Studies on Nitric Oxide Synthase Inhibitors

Journal: Current Enzyme Inhibition
Volume: 12 Issue: 1 Year: 2016 Page: 67-80
Author(s): Satya P. Gupta,Harish Kumar,Basheerulla Shaik

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

Journal: Current Neuropharmacology
Volume: 14 Issue: 5 Year: 2016 Page: 441-454
Author(s): James A.R. Dalton,Isaias Lans,Xavier Rovira,Fanny Malhaire,Xavier Gómez-Santacana,Silvia Pittolo,Pau Gorostiza,Amadeu Llebaria,Cyril Goudet,Jean-Philippe Pin,Jesús Giraldo

Research Article

In Vitro Elucidation of the Folding Intermediates and Aggregate Formation of Hemoglobin Induced by Acetonitrile: A Multispectroscopic Approach

Journal: Protein & Peptide Letters
Volume: 23 Issue: 1 Year: 2016 Page: 884-891
Author(s): Mohammad Furkan, Asim Rizvi, Mohammad Afsar, Mohammad Rehan Ajmal, Rizwan H. Khan, Aabgeena Naeem

In Vitro Inhibition of Glyoxalase І by Flavonoids: New Insights from Crystallographic Analysis

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 4 Year: 2016 Page: 460-466
Author(s): Hong Zhang,Jing Zhai,Liping Zhang,Cuiyun Li,Yining Zhao,Yunyun Chen,Qing Li,Xiao Peng Hu

Modified Hummel-Dreyer Method and Molecular Modeling Studies Identified Nicotinic Acid Analogues as Carbonic Anhydrase III Ligands

Journal: Letters in Drug Design & Discovery
Volume: 13 Issue: 5 Year: 2016 Page: 401-410
Author(s): Nada Jarrar,Muhammed Alzweiri,Yusuf Al-Hiari,Shrouq Farah,Mohammad A. Khanfar

Discovery of Potential Dual Inhibitors Against Lipases Rv0183 and Rv3802c for Tuberculosis Therapeutics

Journal: Letters in Drug Design & Discovery
Volume: 13 Issue: 2 Year: 2016 Page: 185-195
Author(s): Parameswaran Saravanan,Sanjukta Patra

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