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Development of Trypsin-Like Serine Protease Inhibitors as Therapeutic Agents: Opportunities, Challenges, and their Unique Structure-Based Rationales

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 13 Year: 2016 Page: 1506-1529
Author(s): Guyan Liang,J. Phillip Bowen

Antithrombin, an Important Inhibitor in Blood Clots

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 6 Year: 2016 Page: 666-674
Author(s): Ying Zhu,Qing-Wei Cong,Yue Liu,Chun-ling Wan,Tao Yu,Guang He,Lin He,Lei Cai,Kuo-Chen Chou

Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade

Journal: Letters in Drug Design & Discovery
Volume: 13 Issue: 1 Year: 2016 Page: 3-23
Author(s): Andrea Roxanne J. Anas,Ken-ichi Harada

Review Article

G-Quadruplex Aptamers to Human Thrombin Versus Other Direct Thrombin Inhibitors: The Focus on Mechanism of Action and Drug Efficiency as Anticoagulants

Journal: Current Medicinal Chemistry
Volume: 23 Issue: 21 Year: 2016 Page: 2230-2244
Author(s): Elena Zavyalova,Nikita Ustinov,Andrey Golovin,Galina Pavlova,Alexey Kopylov

Research Article

Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 2 Year: 2016 Page: 2379-2430
Author(s): Dmitrii V. Kalinin, Ralph Holl

The Problem of Atrial Fibrillation in Patients with Chronic Kidney Disease

Journal: Current Vascular Pharmacology
Volume: 14 Issue: 3 Year: 2016 Page: 260-265
Author(s): Beata Franczyk,Anna Gluba-BrzÃ³zka,Aleksandra CiaÅkowska-Rysz,Maciej Banach,Jacek Rysz

Design, Synthesis and Bioactivity Evaluation of Novel Dabigatran Derivatives as Potential Thrombin Inhibitors

Journal: Letters in Drug Design & Discovery
Volume: 13 Issue: 8 Year: 2016 Page: 809-817
Author(s): Qianqian Liu, Yujie Ren, Xiaodong Gao

Review Article

Development of Antithrombotic Aptamers: From Recognizing Elements to Drugs

Journal: Current Pharmaceutical Design
Volume: 22 Issue: 33 Year: 2016 Page: 5163-5176
Author(s): Elena Zavyalova,Andrey Golovin,Galina Pavlova,Alexey Kopylov

Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat

Journal: Drug Metabolism Letters
Volume: 10 Issue: 2 Year: 2016 Page: 91-100
Author(s): Peter W. Fan, Jacob Z. Chen, M. Allan Jaochico, Hank La, Ning Liu, Teresa Mulder, Robert T. Cass, Matthew Durk, Kirsten Messick, Nicole Valle, Shannon Liu, Wendy Lee, James J. Crawford, Joachim Rudolf, Lesley J. Murray, S. Cyrus Khojasteh, Matthew Wright

Pharmacogenomics of Oral Antithrombotic Drugs

Journal: Current Pharmaceutical Design
Volume: 22 Issue: 13 Year: 2016 Page: 1933-1949
Author(s): Flavia Storelli,Youssef Daali,Jules Desmeules,Jean-Luc Reny,Pierre Fontana

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