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Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2

Journal: Drug Metabolism Letters
Volume: 6 Issue: 4 Year: 2012 Page: 275-284
Author(s): Jayalakshmi Sridhar, Jamie Ellis, Patrick Dupart, Jiawang Liu, Cheryl L. Stevens, Maryam Foroozesh

Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition

Journal: Current Drug Metabolism
Volume: 13 Issue: 8 Year: 2012 Page: 1145-1159
Author(s): Toshiro Niwa, Hiroshi Yamazaki

Dynamics and Hydration of the Active Sites of Mammalian Cytochromes P450 Probed by Molecular Dynamics Simulations

Journal: Current Drug Metabolism
Volume: 13 Issue: 2 Year: 2012 Page: 177-189
Author(s): Tereza Hendrychova, Karel Berka, Veronika Navratilova, Pavel Anzenbacher, Michal Otyepka

Effects of Interleukin 1Î² (IL-1Î²) and IL-1Î²/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture

Journal: Current Drug Metabolism
Volume: 13 Issue: 7 Year: 2012 Page: 930-937
Author(s): Leslie J. Dickmann,Sonal K. Patel,Larry C. Wienkers,J. Greg Slatter

Effects of Culture Duration on Gene Expression of P450 Isoforms, Uptake and Efflux Transporters in Primary Hepatocytes Cultured in the Absence and Presence of Interleukin- 6: Implications for Experimental Design for the Evaluation of Downregulatory Effects of Biotherapeutics

Journal: Current Drug Metabolism
Volume: 13 Issue: 7 Year: 2012 Page: 938-946
Author(s): Qian Yang,Utkarsh Doshi,Nicole Li,Albert P. Li

Prediction of Cytochrome 450 Mediated Drug-Drug Interactions by Three-Dimensional Cultured Hepatocytes

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 12 Issue: 10 Year: 2012 Page: 1028-1036
Author(s): C. Shen,Q. Meng

Drug Interactions with Normal and TEN Epidermal Keratinocytes

Journal: Current Drug Safety
Volume: 7 Issue: 5 Year: 2012 Page: 352-356
Author(s): Philippe Paquet,Philippe Delvenne,Gerald E. Pierard

De-Risking Bio-therapeutics for Possible Drug Interactions Using Cryopreserved Human Hepatocytes

Journal: Current Drug Metabolism
Volume: 13 Issue: 7 Year: 2012 Page: 923-929
Author(s): Shannon Dallas,Carlo Sensenhauser,Ameesha Batheja,Monica Singer,Maria Markowska,Cindy Zakszewski,Rao N.V.S. Mamidi,Michael McMillia,Chao Han,Honghui Zhou,Jose Silva

Liver-Based In Vitro Technologies for Drug Biotransformation Studies - A Review

Journal: Current Drug Metabolism
Volume: 13 Issue: 2 Year: 2012 Page: 215-224
Author(s): Pius Fasinu, Patrick J. Bouic, Bernd Rosenkranz

Correlation of CYP2B6-516G>T Polymorphism with Plasma Efavirenz Concentration and Depression in HIV-Infected Adults in Northern Thailand

Journal: Current HIV Research
Volume: 10 Issue: 8 Year: 2012 Page: 653-660
Author(s): Linda Aurpibul,Nuntisa Chotirosniramit,Patcharaphan Sugandhavesa,Natthapol Kosashunhanan,Sunida Thetket,Taweewat Supindham,Weerawit Piyamongkol,Khuanchai Supparatpinyo

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