Search Result "bioisosterism"


Syntheses of 2,3-Dihydro-1,4-Benzodioxins and Bioisosteres as Structural Motifs for Biologically Active Compounds

Journal: Current Organic Chemistry
Volume: 15 Issue: 6 Year: 2011 Page: 869-887
Author(s): Olga Cruz-Lopez, Maria C. Nunez, Ana Conejo-Garcia, Maria Kimatrai, Joaquin M. Campos

High Content Pharmacophores from Molecular Fields: A Biologically Relevant Method for Comparing and Understanding Ligands

Journal: Current Computer-Aided Drug Design
Volume: 7 Issue: 3 Year: 2011 Page: 190-205
Author(s): Timothy J. Cheeseright, Mark D. Mackey, Robert A. Scoffin

Design, Synthesis and Bioactivities of Phenylamino-Pyrimidine Derivatives as Novel Protein Tyrosine Kinase Inhibitors

Journal: Letters in Drug Design & Discovery
Volume: 8 Issue: 7 Year: 2011 Page: 596-601
Author(s): Xinfu Hong, Xianzhao Kuang, Guohua Ding, Yilin Liu, Jinlin Liu, Yanjin Zhao, Shuxin Li

Toxicophoric and Metabolic In Silico Evaluation of Benzimidazole and Phenylbenzamide Derivatives with Potential Application as Anticancer Agents

Journal: Drug Metabolism Letters
Volume: 5 Issue: 4 Year: 2011 Page: 267-275
Author(s): Vinicius Barreto da Silva, Andreia Machado Leopoldino, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silva

Small Molecule Inhibitors of NF-κB and JAK/STAT Signal Transduction Pathways as Promising Anti-Inflammatory Therapeutics

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 11 Issue: 1 Year: 2011 Page: 55-78
Author(s): Y. A. Ivanenkov, K. V. Balakin, Y. Lavrovsky

GABAA Receptor Subtype-Selective Modulators. I. α2/α3-Selective Agonists as Non-Sedating Anxiolytics

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 9 Year: 2011 Page: 1176-1202
Author(s): John R. Atack

Novel Substituted Quinazolines for Potent EGFR Tyrosine Kinase Inhibitors

Journal: Current Medicinal Chemistry
Volume: 18 Issue: 7 Year: 2011 Page: 943-963
Author(s): O. Cruz-Lopez, A. Conejo-Garcia, M. C. Nunez, M. Kimatrai, M. E. Garcia-Rubino, F. Morales, V. Gomez-Perez, J. M. Campos

Editorial [Hot Topic: 2-Isoxazolines in Synthesis (Guest Editor: Cindy C. Browder)]

Journal: Current Organic Synthesis
Volume: 8 Issue: 5 Year: 2011 Page: 615-615
Author(s): Cindy C. Browder

Glutamate Binding-Site Ligands of NMDA Receptors

Journal: Current Medicinal Chemistry
Volume: 18 Issue: 3 Year: 2011 Page: 5483-5506
Author(s): C. Bonaccorso, N. Micale, R. Ettari, S. Grasso, M. Zappala

Modern Drug Discovery Technologies: Opportunities and Challenges in Lead Discovery

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 14 Issue: 1 Year: 2011 Page: 830-839
Author(s): Rafael V. C. Guido, Glaucius Oliva, Adriano D. Andricopulo

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