Search Result "allosteric modulators"


Progress in the Developement of Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

Journal: Current Medicinal Chemistry
Volume: 18 Issue: 1 Year: 2011 Page: 47-68
Author(s): A. A. Trabanco, J. M. Cid, H. Lavreysen, G. J. Macdonald, G. Tresadern

Identification and Characterization of mGlu3 Ligands Using a High Throughput FLIPR Assay for Detection of Agonists, Antagonists, and Allosteric Modulators

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 14 Issue: 7 Year: 2011 Page: 631-641
Author(s): Steven D. Pratt, Mario Mezler, Herve Geneste, Margot H.M. Bakker, Philip J. Hajduk, Sujatha M. Gopalakrishnan

mGluR5 Negative Allosteric Modulators Overview: A Medicinal Chemistry Approach Towards a Series of Novel Therapeutic Agents

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 6 Year: 2011 Page: 680-695
Author(s): Jean-Philippe Rocher, Beatrice Bonnet, Christelle Bolea, Robert Lutjens, Emmanuel Le Poul, Sonia Poli, Mark Epping-Jordan, Anne-Sophie Bessis, Bernard Ludwig, Vincent Mutel

The Molecular Chaperone Hsp70 Family Members Function by a Bidirectional Heterotrophic Allosteric Mechanism

Journal: Protein & Peptide Letters
Volume: 18 Issue: 2 Year: 2011 Page: 132-142
Author(s): Kelly P. da Silva, Julio C. Borges

Metabotropic Glutamate Receptors as Targets for Analgesia: Antagonism, Activation, and Allosteric Modulation

Journal: Current Pharmaceutical Biotechnology
Volume: 12 Issue: 1 Year: 2011 Page: 1681-1688
Author(s): Michael C. Montana, Robert W. Gereau

α7 Nicotinic Acetylcholine Receptor as a Potential Therapeutic Target for Schizophrenia

Journal: Current Pharmaceutical Design
Volume: 17 Issue: 2 Year: 2011 Page: 121-129
Author(s): Masatomo Ishikawa, Kenji Hashimoto

A Hydrazide Linker Strategy for Heterobivalent Compounds as Ortho- and Allosteric Ligands of Acetylcholine-Binding Proteins

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 2 Year: 2011 Page: 2731-2748
Author(s): Paul W. Elsinghorst, Wolfgang Hartig, Daniela Gundisch, Klaus Mohr, Christian Trankle, Michael Gutschow

A Closer Look at the High Affinity Benzodiazepine Binding Site on GABAA Receptors

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 2 Year: 2011 Page: 241-246
Author(s): Erwin Sigel, Benjamin P. Luscher

Non Genomic Modulation of Ligand Gated Ionotropic Receptors by Thyroid Hormones

Journal: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry
Volume: 11 Issue: 3 Year: 2011 Page: 179-187
Author(s): Giulia Puia

Epigenetic Multiple Modulators

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 2 Year: 2011 Page: 2749-2787
Author(s): Rosana Alvarez, Lucia Altucci, Hinrich Gronemeyer, Angel R. de Lera

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