Search Result "ADME profiling"


Research Article

Structure-Based Drug Design, Molecular Dynamics and ADME/Tox to Investigate Protein Kinase Anti-Cancer Agents

Journal: Current Bioactive Compounds
Volume: 13 Issue: 3 Year: 2017 Page: 213-222
Author(s): Evelyn M.L.P. Diniz,João G.C. Poiani,Carlton A. Taft,Carlos H.T.P. da Silva

Review Article open access plus

A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015

Journal: Current Medicinal Chemistry
Volume: 24 Issue: 29 Year: 2017 Page: 3159-3184
Author(s): Zhihong O`Brien,Mehran F. Moghaddam

Research Article

Molecular and Thermodynamic Studies on DNA Triplex Formed in the Promoter Region of HMGB1 Gene as a Selective Target for Anticancer Drugs

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 17 Issue: 1 Year: 2017 Page: 1698-1709
Author(s): Lohani Neelam,Moganty R. Rajeswari

Review Article

ADME Considerations for the Development of Biopharmaceutical Conjugates Using Cleavable Linkers

Journal: Current Topics in Medicinal Chemistry
Volume: 17 Issue: 3 Year: 2017 Page: 3444-3462
Author(s): L. Nathan Tumey,Sean Han

Research Article

Physicochemical Characterization of Mitragyna speciosa Alkaloid Extract and Mitragynine using In Vitro High Throughput Assays

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 20 Issue: 9 Year: 2017 Page: 796-803
Author(s): Wai Mun Kong,Zamri Chik,Zahurin Mohamed,Mohammed A. Alshawsh

Research Article

Grid-independent Descriptors (GRIND) Analysis and SAR Guided Molecular Docking Studies to Probe Selectivity Profiles of Inhibitors of Multidrug Resistance Transporters ABCB1 and ABCG2

Journal: Current Cancer Drug Targets
Volume: 17 Issue: 2 Year: 2017 Page: 177-190
Author(s): Talha Shafi,Ishrat Jabeen

Research Article

Molecular Docking and Structure Activity Relationship Studies of NSAIDs. What do they Reveal about IC50?

Journal: Letters in Drug Design & Discovery
Volume: 14 Issue: 8 Year: 2017 Page: 949-958
Author(s): Chrysoula Mikra,Georgios Rossos,Sotirios K. Hadjikakou,Nikolaos Kourkoumelis

Research Article

Molecular Docking and In Silico ADMET Study Reveals Flavonoids as a Potential Inhibitor of Aromatase

Journal: Letters in Drug Design & Discovery
Volume: 14 Issue: 11 Year: 2017 Page: 1267-1276
Author(s): Umang Shah,Samir Patel,Mehul Patel,Jagat Upadhayay

Research Article

Design, Synthesis and Biological Evaluation of Novel 1, 3- thiazolidine-2, 4-diones as Anti-prostate Cancer Agents

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 17 Issue: 1 Year: 2017 Page: 1756-1768
Author(s): Ramakrishnan Elancheran,Kuppusamy Saravanan,Selvaraj Divakar,Sima Kumari,V. Lenin Maruthanila,Senthamarikannan Kabilan,Muthiah Ramanathan,Rajlakshmi Devi,Jibon Kotoky

Review Article

Developmental Pharmacokinetics in Neonates: Maturational Changes and Beyond

Journal: Current Pharmaceutical Design
Volume: 23 Issue: 3 Year: 2017 Page: 5769-5778
Author(s): Karel Allegaert,Paola Mian,John N. van den Anker

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