Search Result "lead optimization"


Natural Lead Compounds and Strategies for Optimization

Ebook: Recent Advances in Anesthesiology
Volume: 4 Year: 2018
Author(s): Dev Bukhsh Singh

Advances in the Integration of Drug Metabolism into the Lead Optimization Paradigm

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 9 Issue: 6 Year: 2009 Page: 703-716
Author(s): Walter A. Korfmacher

Linear Interaction Energy (LIE) Method in Lead Discovery and Optimization

Journal: Current Drug Targets
Volume: 9 Issue: 1 Year: 2008 Page: 1100-1105
Author(s): Hermes Luis Neubauer de Amorim, Rafael Andrade Caceres, Paulo Augusto Netz

Exploring Natural Products as a Source for Antidiabetic Lead Compounds and Possible Lead Optimization

Journal: Current Topics in Medicinal Chemistry
Volume: 16 Issue: 2 Year: 2016 Page: 2549-2561
Author(s): Reema Abu Khalaf

Structure Based Lead Optimization Approach in Discovery of Selective DPP4 Inhibitors

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 13 Issue: 6 Year: 2013 Page: 888-914
Author(s): Manjunath Ghate, Shailesh V. Jain

Computer-Aided Drug Design: Lead Discovery and Optimization

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 15 Issue: 4 Year: 2012 Page: 328-337
Author(s): Mingli Xiang, Yu Cao, Wenjie Fan, Lijuan Chen, Yirong Mo

Review Article

The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization

Journal: Current Medicinal Chemistry
Volume: 26 Issue: 2 Year: 2019 Page: 3838-3873
Author(s): Agostino Bruno,Gabriele Costantino,Luca Sartori,Marco Radi

Novel, Acidic CCR2 Receptor Antagonists: Lead Optimization

Journal: Letters in Drug Design & Discovery
Volume: 4 Issue: 4 Year: 2007 Page: 263-271
Author(s): O. A. Dasse, J. L. Evans, H.-X. Zhai, D. Zou, J. T. Kintigh, F. Chan, K. Hamilton, E. Hill, J. B. Eckman, P. J. Higgins, A. Volosov, P. Collart, J.-M. Nicolas, R.K. Kondru, C.E. Schwartz

Utility of NMR in Lead Optimization: Fragment-Based Approaches

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 5 Issue: 8 Year: 2002 Page: 631-643
Author(s): Jeffrey R. Huth, Chaohong Sun

Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

Journal: Current Topics in Medicinal Chemistry
Volume: 12 Issue: 5 Year: 2012 Page: 473-483
Author(s): Arnab K. Chatterjee, Bryan K.S. Yeung

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