Search Result "PDK1"

Targeting PDK1 in Cancer

Journal: Current Medicinal Chemistry
Volume: 18 Issue: 1 Year: 2011 Page: 2763-2769
Author(s): C. Raimondi, M. Falasca

A New Molecular Target of Insulin Action: Regulating the Pivotal PDK1

Journal: Current Drug Targets - Immune, Endocrine & Metabolic Disorders
Volume: 1 Issue: 3 Year: 2001 Page: 209-221
Author(s): K.L.R. Wick, F. Liu

Research Article

Ligand Based Pharmacophore Modeling Followed by Biological Screening Lead to Discovery of Novel PDK1 Inhibitors as Anticancer Agents

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 20 Issue: 4 Year: 2020 Page: 476-485
Author(s): Iman Mansi,Mahmoud A. Al-Sha'er,Nizar Mhaidat,Mutasem Taha

Research Article

Investigation of Binding Characteristics of Phosphoinositide-dependent Kinase-1 (PDK1) Co-crystallized Ligands Through Virtual Pharmacophore Modeling Leading to Novel anti – PDK1 Hits

Journal: Medicinal Chemistry
Volume: 16 Issue: 7 Year: 2020 Page: 860-880
Author(s): Iman A. Mansi,Mahmoud A. Al-Sha`er,Nizar M. Mhaidat,Mutasem O. Taha,Rand Shahin

Efficient Identification of Novel Leads by Dynamic Focused Screening: PDK1 Case Study

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 13 Issue: 1 Year: 2010 Page: 16-26
Author(s): Dongyu Sun, Joon Jung, Thomas S. Rush III, Zangwei Xu, Michael J. Weber, Ekaterina Bobkova, Alan Northrup, Ilona Kariv

Research Article

PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 20 Issue: 7 Year: 2020 Page: 828-833
Author(s): Xiaohua Zhang,Shan Zhong

A Preliminary Assessment of the Structure-Activity Relationship of Benzimidazole-Based Anti-Proliferative Agents

Journal: Letters in Drug Design & Discovery
Volume: 5 Issue: 6 Year: 2008 Page: 369-376
Author(s): Leyte L. Winfield, Dayle M. Smith, Kalani Halemano, Carmine S. Leggett

Research Article

Fisetin Attenuates AKT Associated Growth Promoting Events in AflatoxinB1 Induced Hepatocellular Carcinoma

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 18 Issue: 1 Year: 2018 Page: 1885-1891
Author(s): Brajesh K. Maurya,Surendra K. Trigun

The SeeDs Approach: Integrating Fragments into Drug Discovery

Journal: Current Topics in Medicinal Chemistry
Volume: 7 Issue: 1 Year: 2007 Page: 1568-1581
Author(s): Roderick E. Hubbard, Ben Davis, Ijen Chen, Martin J. Drysdale

Druggability of Dynamic Protein-protein Interfaces

Journal: Current Pharmaceutical Design
Volume: 18 Issue: 3 Year: 2012 Page: 4599-4606
Author(s): Ozlem Ulucan, Susanne Eyrisch, Volkhard Helms

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