<![CDATA[Fatigue Syndrome, Chronic]]> https://www.eurekaselect.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Sat, 13 Apr 2024 03:54:49 +0000 <![CDATA[Fatigue Syndrome, Chronic]]> https://www.eurekaselect.com https://www.eurekaselect.com <![CDATA[High Sensitivity C-Reactive Protein as a Potential Biomarker of Neuroinflammation in Major Psychiatric Disorders]]>https://www.eurekaselect.comarticle/91619

Objectives: Reviewing the recent literature upon: neuroinflammation in mood and schizophrenic disorders, the potential use of HSCRP as an inflammatory biomarker in psychiatric disorders and its possible use for the stratification of risk.

Method: The authors conducted a MedLine/PubMed search of all articles up to January 2017 using five keywords. The search was supplemented with a manual review of relevant references. Evidences assessing the relationship between CRP plasma levels and psychiatric disorders have been reviewed.

Result: Elevated High-Sensitivity CRP (HSCRP) plasma levels have been reported specially in mood disorders, mainly in mania and in a subset of patients with Depression. Childhood trauma and suicidal behaviour represent factors that increase illness vulnerability and influence immune responses. The complex interaction amongst immune and endocrine systems, metabolic parameters and psychopharmacological effects enhance difficulty in understanding the directionality of this relationship.

Conclusion: The heterogeneity of findings provided by research could suggest the presence of genetically determined or epigenetic factors in a subgroup of individuals who react to stress factors with an inflammatory hyperactivation. HSCRP could represent a useful biomarker to identify patients with greater risk to develop medical comorbidities that could benefit from anti-inflammatory treatments.]]> <![CDATA[Early Life Stress in Depressive Patients: Role of Glucocorticoid and Mineralocorticoid Receptors and of Hypothalamic-Pituitary-Adrenal Axis Activity]]>https://www.eurekaselect.comarticle/64339 <![CDATA[Processed Foods, Dysbiosis, Systemic Inflammation, and Poor Health]]>https://www.eurekaselect.comarticle/50834

Modern molecular biology techniques have made it possible to explore the mechanisms behind these catastrophic effects of modern living. It is a 50-year-old observation that beneficial bacteria like lactobacilli do not grow well when exposed to food ingredients such casein (dairy) and gluten (wheat, rye and barley). More recent Studies demonstrate that human microbiota and its functions compared to rural minorities, are more than 90 % reduced in Western individuals, and further reduced by exposure to chemicals, including pharmaceuticals. The ultimate consequence of these changes is that body membranes lose their tightness and start leaking; such leakage often documented for all body membranes; effects observed in barriers such as in the gut, airways, skin, oral cavity, vagina, nose, eye cavity, placenta and blood-brain barrier. The consequence of this is leakage over the membranes of various damaging toxins of microbial origin such as endotoxins, but also food-derived proteotoxins such as casein, gluten and zein and toxins producing by heating foods to high temperature (grilling, roasting, baking etc) and production of glycated and lipoxidated molecules (AGEs and ALEs). Furthermore, bacterial debris and whole dead or live bacteria will leak and found in the fat of obese and the plaques of individuals with arteriosclerosis. Recent studies report not only reduced numbers and diversity of bacteria in microbiota of individuals with various diseases, but also totally different microbial species in individuals with obesity and various diseases.

Attempts to treat diseases by supplying probiotics have only been partly, and at the best temporarily, successful, when applied without any changes in food habits. Furthermore, probiotics are not compatible with pharmacological and other toxic chemicals. Eco-biological treatments, with plant-derived substances, or phytochemicals, e.g. curcumin and resveratrol, and pre-, pro- and synbiotics offer similar effects as use of drugs referred to asbiologicals, although milder but also without adverse effects. Such treatments should be tried as alternative therapies; mainly, to begin with, for disease prevention but also in early cases of chronic diseases. Dramatic alterations, in direction of a paleolithic-like lifestyle and food habits, appear, as we see it today, the only alternative to control the present escalating global health crisis.]]> <![CDATA[Non-Analgesic Effects of Opioids: Opioids and the Endocrine System]]>https://www.eurekaselect.comarticle/46694 <![CDATA[ Stress as a Pathophysiological Factor in Functional Somatic Syndromes]]>https://www.eurekaselect.comarticle/33457