<![CDATA[Dextrocardia]]> https://www.eurekaselect.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Sun, 14 Jul 2024 17:14:35 +0000 <![CDATA[Dextrocardia]]> https://www.eurekaselect.com https://www.eurekaselect.com <![CDATA[Cardiac Axis in Early Gestation and Congenital Heart Disease]]>https://www.eurekaselect.comarticle/137797Congenital heart defects represent the most common structural anomalies observed in the fetal population, and they are often associated with significant morbidity and mortality.

The fetal cardiac axis, which indicates the orientation of the heart in relation to the chest wall, is formed by the angle between the anteroposterior axis of the chest and the interventricular septum of the heart. Studies conducted during the first trimester have demonstrated promising outcomes with respect to the applicability of cardiac axis measurement in fetuses with congenital heart defects as well as fetuses with extracardiac and chromosomal anomalies, which may result in improved health outcomes and reduced healthcare costs.

The main aim of this review article was to highlight the cardiac axis as a reliable and powerful marker for the detection of congenital heart defects during early gestation, including defects that would otherwise remain undetectable through the conventional four-chamber view.]]> <![CDATA[Primary Ciliary Dyskinesia - An Update on the Genetics of Underlying Pathological Mechanisms]]>https://www.eurekaselect.comarticle/132260 <![CDATA[Notch Signalling Pathways and Their Importance in the Treatment of Cancers]]>https://www.eurekaselect.comarticle/82213

Objective: In the present review, we highlight the Notch signalling pathway components i.e. Notch receptors, ligands, effector, and their regulators. We also discuss the tumor biology of the Notch pathway involved in various cancers.

Results: Interestingly, the Notch signalling pathway is dysregulated in many cancers. Notch may serve as oncogene or tumor suppressor and plays an important role in cancers of the liver, pancreas, endometrium of uterus, ovary, prostate, bladder and colon. The activation of Notch pathway plays a vital role in the progression of some cancer. In addition, Notch pathway activation was also shown to drive chemoresistance in cancer, as well. Chemotherapeutically, combined NOTCH1 inhibitor synergistically attenuated chemotherapy-enriched cancer stem cell population both in vitro and in vivo. This may prove to be beneficial in the treatment of cancer.

Conclusion: The Notch inhibitors possess anti-proliferative effects on cancer, thereby serving as a new treatment for cancer.]]> <![CDATA[Tetralogy of Fallot and Hypoplastic Left Heart Syndrome – Complex Clinical Phenotypes Meet Complex Genetic Networks]]>https://www.eurekaselect.comarticle/65637 <![CDATA[ Left-Right Asymmetry in Embryonic Development and Breast Cancer: Common Molecular Determinants?]]>https://www.eurekaselect.comarticle/20744 <![CDATA[ Heart Transplantation in Biventricular Congenital Heart Disease: Indications, Techniques, and Outcomes]]>https://www.eurekaselect.comarticle/20272