How to Build a Drug: Exercises Based on the Concept of Retrosynthetic Analysis

Abstract

Concepts involving retrosynthesis were and are essential to the development of organic synthesis as science and art. Therefore, the first four exercises are based on this concept. These exercises were subdivided into themes and degrees of increasing difficulty so that the reader could gradually progress and become familiar with their concepts. Thus, the first exercise begins with the retrosynthetic analysis of drugs based on the identification of only two synthons and their respective synthetic equivalents (reagents and substances) necessary for their synthesis. Exercises 2, 3, and 4 are thematic and based on the identification of epoxides, piperazines, and aldehydes, used in the synthesis of drugs and bioactive substances as well as other synthons and their respective synthetic equivalents present in the exercises.

Keywords: Aldehydes, Drugs, Epoxides, Exercises, Medicinal chemistry, Organic synthesis, Piperazines, Reagentes, Retrosynthetic analysis, Substances, Synthons.