Genetics of Malignant Pleural Mesothelioma

Author(s): Dean A. Fennell, Annabel J. Sharkey and Sara Busacca

Pp: 155-168 (14)

* (Excluding Mailing and Handling)

Abstract

Malignant pleural mesotheliomais characterised by a large range of complex genetic alterations and peculiarof this disease. The mesothelioma genome contains extensive copy number alterations and aneuploidy which may correlate with response to treatment and survival. The genetics of mesothelioma has increased considerably over the last decade with major advances in whole genome and next generation sequencing. The knowledge of the genomics of mesothelioma is essential for identifying new, effective personalised therapeutic approaches therapies for improving clinical outcomes in patients with mesothelioma.

Keywords: BAP1, CDKN2A/ARF, chromosomal loss, comparative genomic hybridisation, Genetics, hypermethylation, NF2/Merlin.

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