Advances in Biomedical Sciences and Engineering

Strontium Containing Bioactive Bone Cement for Orthopedic Applications

Author(s): Zhaoyang Li, Keith Dip-Kei Luk and William Weijia Lu

Pp: 69-81 (13)

DOI: 10.2174/978160805040610901010069

* (Excluding Mailing and Handling)


Strontium (Sr) and related compounds have become more attractive in the prevention and treatment of osteoporosis. Previously, we developed a novel bioactive bone cement, which mainly composed of strontium-containing hydroxyapatite (Sr-HA) filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) resin. This bone cement is superior to conventional polymethylmethacrylate (PMMA) bone cement in bioactivity, biocompatibility, and osseointegration. It also has shown sufficient mechanical strength properties for its use in percutaneous vertebroplasty (PVP) and total hip replacement (THR). In this chapter, we reviewed the in vitro, in vivo, and clinical evidence for the effectiveness of this bioactive bone cement.

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