From SARS-CoV to MARS-CoV

Genetic Architecture of Host Proteins Involved in SARS-CoV

Author(s): Hayat Khan, Firasat Hussain*, Muhammad Adnan, Muhammad Naveed Nawaz, Inam Ullah Khan, Umair Younas, Muhammad Nisar, Imtiaz Ali Khan, Muhammad Kalim, Chen Shanyuan and Amjad Islam Aqib

Pp: 145-196 (52)

DOI: 10.2174/9789815274943124010008

* (Excluding Mailing and Handling)

Abstract

The coronavirus spontaneously mutates and produces new strains overtime. A few variants are more infectious and harmful than others. Additionally, certain variations are capable of eluding treatment control. These modifications may have an impact on the virus's features. The novel variations have the power to progress quickly and induce pathogenicity. Vaccines, diagnostic tools, active compounds, and other precautionary care may also be affected by novel variations. At first, it was considered that cells could also ingest and destroy infections in addition to degrading cellular contents. This mechanism was later confirmed for other viruses and given the label xenophagy. Because of the modification of the coronavirus, poor and emerging nations are constantly confronted with new issues. Developing nations must promptly prepare and create a clear direction to vaccinate their entire population. It has frequently been questioned if vaccination can entirely safeguard someone from a virus that alters its features quickly and produces variations with more powerful alterations. However, much evidence is that immunization prevents the virus from spreading and protects people.


Keywords: Emerging, Genome, Immunization, Immune response, Mutations, New strains, Pathogenicity, Spike, SARS-CoV, Variants, Vaccination.

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