Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer

Novel Implications of Prognostic Markers to Monitor the Disease: An Overview

Author(s): Rohit Saxena, Ankit Gupta, Vikrant Singh, Vipin Kumar Singh, Sagar Kumar and Rashmi Mittal * .

Pp: 182-197 (16)

DOI: 10.2174/9789815079784123010012

* (Excluding Mailing and Handling)


Apart from the absence of targeted therapies, poor prognosis in TNBC has affected the clinical outcome of the disease and has led to cause high mortality rate amongst diseased individuals. The discovery of potential biomarkers to determine the prognostic and predictive value may play a vital role in the development of an effective therapeutic approach and may improve the OS, DFS, and DMFS. This chapter highlighted the role of histological subtyping, lymph node status, lymphovascular invasion, miRNA, Ki-67, TILs, and BRCAness as prognostic markers of diseases. Nevertheless, patient selection and choice of treatment strategy will greatly impact the clinical efficacy of these prognostic markers but will remain to be a matter of further exploration.

Keywords: Kaplan-Meier, Ki-67, Lymph-node, Lymphovascular, MiRNA, Prognosis, Tumor.

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