Therapeutic Drug Targets and Phytomedicine For Triple Negative Breast Cancer

Phyto-nanotechnology: Enhancing Plant Based Chemical Constituent Mediated Anticancer Therapies

Author(s): Usman Umar Zango, Aminu Abubakar, Rohit Saxena and Vedpriya Arya * .

Pp: 161-181 (21)

DOI: 10.2174/9789815079784123010011

* (Excluding Mailing and Handling)

Abstract

95% of anti-cancer agents were associated with the worst pharmaceutical and pharmacokinetic properties including poor targeted cellular uptake, shorter halflife, toxicity, and many more. In this regard, nanotechnology including nanomedicines, nano-carriers, and nanomaterials may emerge as a beneficial tool to facilitate an efficient delivery of therapeutic regimens by adapting active or passive targeting mechanisms. The nanotechnology-based delivery system of phytoconstituents can efficiently battle against recalcitrant TNBC. This chapter highlighted the nanotechnology-based therapeutic approach including smart nanoparticles, cell membrane-coated nanoparticles, and immunological cell-based nano-systems for the treatment of TNBC. Furthermore, the role of nano-soldiers in improving bioavailability and targeted drug delivery was highlighted. Nano conjugates of curcumin, anacardic acid, EGCG, betulinic acid, gambogic acid, and resveratrol were also evaluated to enhance the pharmacokinetic profile, distribution, and the release rate of respective compounds and ultimately their ability to target TNBC.


Keywords: Absorption, BCSCs, Bioavailability, Curcumin, Drug efflux, EGCG, Lymphatic drainage, Metabolism, Nano-medicine, Nano-soldiers, Pharmaceutics, Phyto-nanotechnology, Rapid elimination, Resveratrol, SDDS, Systemic release, Targeted delivery.

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