Superior Aspects of Liquid Chromatography- Based Mass Spectrometers in Chiral Analysis

Pp: 1-31 (31)

* (Excluding Mailing and Handling)

Chirality has many important roles in life activities because enzymes, amino

acids, nucleic acids, carbohydrates, fats, metabolic intermediates, and many other types

of biomolecules are chiral. Due to the different properties of enantiomers, chirality is

important in biological systems, and it is also critically important in many other fields,

such as the pharmaceutical industry, chemical industry, petrochemical industry, food

industry, and agrochemicals, particularly, medicine. Roughly 56% of the

pharmaceuticals currently in use are chiral, and 88% of these are administered in

racemic proportions, while single-enantiomer formulations of some marketed drugs

have shown the higher potency of one stereoisomer compared to the other. Although

they have the same chemical structures, most of the enantiomers present in racemic

drugs have different pharmacokinetic, pharmacodynamic, biological, and toxic effects.

The amounts of chiral molecules in different matrices are far below the levels required

for the analysis of pharmaceutical preparations. Therefore, high resolution and

sensitivity are needed to analyze chiral molecules. Mass spectrometers, which

generally offer higher levels of sensitivity than conventional detection systems and

accordingly allow the analysis of lower levels of analytes, have made large

contributions to separation and detection science. Developments in new types of

columns, different analysis modes, different matrices, and pharmaceutics will be

explored in this chapter. The parameters will be discussed with the pros and cons

together with their applicability to different sample types.

Keywords: Bioanalysis, Biological Material, Chiral Analysis, Chiral Columns, Chirality, Enantiomers, ESI, GC-MS, IM-MS, LC-MS, Mass Spectrometer, MS/MS, Pharmaceutical Preparation, Plasma, QTOF-MS.

Cite as

Current Chinese Science

Anti-Cancer Agents in Medicinal Chemistry

Current Computer-Aided Drug Design

Current Bioactive Compounds

Current Medicinal Chemistry

Current Topics in Chemistry

The Natural Products Journal

Current Catalysis

Current Chinese Chemistry

Combinatorial Chemistry & High Throughput Screening

A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth

Advances in Mathematical Chemistry and Applications

Advances in Mathematical Chemistry and Applications Volume 1 (Revised Edition)

Advances in Organic Synthesis

DOI https://doi.org/10.2174/9789815036930122050003	Print ISSN 2542-5617
Publisher Name Bentham Science Publisher	Online ISSN 2542-5625

Recent Advances in Analytical Techniques