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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Review Article

Metformin: Up to Date

Author(s): Silvia Sciannimanico, Franco Grimaldi, Fabio Vescini, Giovanni De Pergola , Massimo Iacoviello, Brunella Licchelli , Edoardo Guastamacchia , Vito A. Giagulli and Vincenzo Triggiani *

Volume 20 , Issue 2 , 2020

Page: [172 - 181] Pages: 10

DOI: 10.2174/1871530319666190507125847

Price: $65


Background: Metformin is an oral hypoglycemic agent extensively used as first-line therapy for type 2 diabetes. It improves hyperglycemia by suppressing hepatic glucose production and increasing glucose uptake in muscles. Metformin improves insulin sensitivity and shows a beneficial effect on weight control. Besides its metabolic positive effects, Metformin has direct effects on inflammation and can have immunomodulatory and antineoplastic properties.

Aim: The aim of this narrative review was to summarize the up-to-date evidence from the current literature about the metabolic and non-metabolic effects of Metformin.

Methods: We reviewed the current literature dealing with different effects and properties of Metformin and current recommendations about the use of this drug. We identified keywords and MeSH terms in Pubmed and the terms Metformin and type 2 diabetes, type 1 diabetes, pregnancy, heart failure, PCOS, etc, were searched, selecting only significant original articles and review in English, in particular of the last five years.

Conclusion: Even if many new effective hypoglycemic agents have been launched in the market in the last few years, Metformin would always keep a place in the treatment of type 2 diabetes and its comorbidities because of its multiple positive effects and low cost.

Keywords: Metformin, type 2 diabetes, type 1 diabetes, insulin resistance, polycystic ovary syndrome, heart failure.

Graphical Abstract
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