Generic placeholder image

Current Bioactive Compounds

Editor-in-Chief

ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Review Article

Antipyretic Plants: An Updated Review

Author(s): Vandana Garg and Rohit Dutt*

Volume 16 , Issue 1 , 2020

Page: [4 - 12] Pages: 9

DOI: 10.2174/1573407215666190401151844

Price: $65

Abstract

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature.

Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects.

Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity.

Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases.

Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

Keywords: Fever, pyrexia, antipyretic plants, NSAIDS, antibiotics, flavivirus.

Graphical Abstract
[1]
Ivanoff, B. Typhoid fever: Global situation and WHO recommendations. Southeast Asian J. Trop. Med. Public Health, 1995, 26(2), 1-6.
[2]
Ahsan, T. Dengue fever: A regular epidemic? J. Pak. Med. Assoc., 2008, 58(1), 1-2.
[PMID: 18297964]
[3]
Singhi, S.; Kissoon, N.; Bansal, A. Dengue and dengue hemorrhagic fever: management issues in an intensive care unit. J. Pediatr. (Rio J.), 2007, 83(2)(Suppl.), S22-S35.
[http://dx.doi.org/10.1590/S0021-75572007000300004] [PMID: 17530136]
[4]
Chiu, C.Y.; Wu, L.K.; Kuo, H.C. Gastrointestinal bleeding: Endoscopic findings and management of dengue patients. Am. J. Trop. Med. Hyg., 2005, 73, 441-444.
[http://dx.doi.org/10.4269/ajtmh.2005.73.441] [PMID: 16103618]
[5]
Crump, J.A.; Luby, S.P.; Mintz, E.D. The global burden of typhoid fever. Bull. World Health Organ., 2004, 82(5), 346-353.
[PMID: 15298225]
[6]
Mackowiak, P.A. Fever: Basic mechanisms and management. Philadelphia: Lippincott-Raven, 1997, 2, 207-213.
[7]
Tripathi, K.D. Essentials of Medical Pharmacology, 5th Ed.; Jaypee Brothers, Medical publishers (P): Ltd, New Delhi, 2003, pp. 167-184.
[8]
Goodmann and Gilmann. The pharmacological basis of therapeutics, 2nd ed; Laurence Brunton, 1941, pp. 305-307.
[9]
Khan, A.M.; Yousaf, M.N.; Mahmood, T. Current trends in the management of Typhoid fever. Gomal J. Med. Sci., 2004, 2(2), 59-63.
[10]
Nanda, B.K.; Jena, R.; Rath, B.; Behera, B.R. Analgesic and antipyretic activity of whole parts of Sphaeranthus indicus. Linn. J. Chem. Pharm. Res., 2009, 1(1), 207-212.
[11]
Sharma, J.P.; Srivastava, A.; Thakur, S.P.; Barpete, P.K.; Singh, S. Herbal medicine as antipyretic: A comprehensive review. IJPLS, 2010, 1(1), 18-22.
[12]
Maurya, U.; Srivastava, S. Traditional Indian herbal medicine used as antipyretic, antiulcer, anti-diabetic and anticancer: A review. Int. J. Res. Pharm. Chem., 2011, 1(4), 1152-1159.
[13]
Devi, B.P.; Boominathan, R.; Mandal, S.C. Anti-inflammatory, analgesic and antipyretic properties of Clitoria ternatea root. Fitoterapia, 2003, 74(4), 345-349.
[http://dx.doi.org/10.1016/S0367-326X(03)00057-1] [PMID: 12781804]
[14]
Begum, S.; Saxena, B.; Goyal, M.; Ranjan, R.; Joshi, V.B.; Rao, ChV.; Krishnamurthy, S.; Sahai, M. Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan. Fitoterapia, 2010, 81(3), 178-184.
[http://dx.doi.org/10.1016/j.fitote.2009.08.024] [PMID: 19720117]
[15]
Narayanan, N.; Thirugnanasambantham, P.; Viswanathan, S.; Kannappa Reddy, M.; Vijayasekaran, V.; Sukumar, E. Antipyretic, antinociceptive and anti-inflammatory activity of Premna herbacea roots. Fitoterapia, 2000, 71(2), 147-153.
[http://dx.doi.org/10.1016/S0367-326X(99)00132-X] [PMID: 10727811]
[16]
Al-Ghamdi, M.S. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J. Ethnopharmacol., 2001, 76(1), 45-48.
[http://dx.doi.org/10.1016/S0378-8741(01)00216-1] [PMID: 11378280]
[17]
Taesotikul, T.; Panthong, A.; Kanjanapothi, D.; Verpoorte, R.; Scheffer, J.J.C. Anti-inflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir. J. Ethnopharmacol., 2003, 84(1), 31-35.
[http://dx.doi.org/10.1016/S0378-8741(02)00264-7] [PMID: 12499073]
[18]
Panthong, A.; Kanjanapothi, D.; Taesotikul, T.; Wongcome, T.; Reutrakul, V. Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore. J. Ethnopharmacol., 2003, 85(1), 151-156.
[http://dx.doi.org/10.1016/S0378-8741(02)00368-9] [PMID: 12576214]
[19]
Gupta, M.; Mazumder, U.K.; Kumar, R.S.; Gomathi, P.; Rajeshwar, Y.; Kakoti, B.B.; Selven, V.T. Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. J. Ethnopharmacol., 2005, 98(3), 267-273.
[http://dx.doi.org/10.1016/j.jep.2005.01.018] [PMID: 15814258]
[20]
Nisar, M.; Khan, I.; Simjee, S.U.; Gilani, A.H. Obaidullah; Perveen, H. Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc. J. Ethnopharmacol., 2008, 116(3), 490-494.
[http://dx.doi.org/10.1016/j.jep.2007.12.021] [PMID: 18308491]
[21]
Shah, A.S.; Alagawadi, K.R. Anti-inflammatory, analgesic and antipyretic properties of Thespesia populnea Soland ex. Correa seed extracts and its fractions in animal models. J. Ethnopharmacol., 2011, 137(3), 1504-1509.
[http://dx.doi.org/10.1016/j.jep.2011.08.038] [PMID: 21893182]
[22]
Balakrishnan, A.; Balasubramaniyam, P.D.; Natesan, S.K. Antipyretic activity of Zizyphus jujuba lam leaves. J. Adv. Scientific Res., 2012, 3(3), 40-42.
[23]
Chattopadhyay, D.; Arunachalam, G.; Mandal, A.B.; Mandal, S.C. Evaluation of antipyretic activity of leaf extracts of Mallotus peltatus (Geist) Muell. arg. var acuminatus: A folk medicine. Phytomedicine, 2002, 9(8), 727-730.
[http://dx.doi.org/10.1078/094471102321621331] [PMID: 12587693]
[24]
Rajasekaran, A.; Arivukkarasu, R.; Murugesh, S. Evaluation of antipyretic activity of ethyl acetate extract of Adenema hyssopifolium G. Don in a rat model; Asian Pac. J. Trop, 2010, pp. 523-526.
[25]
Bagepalli, S.; Kumar, A.; Lakshman, K.; Jayaveera, K.N. Comparative antipyretic activity of methanolic extracts of some species of Amaranthus. Asian Pac. J. Trop, 2011, 47-50
[http://dx.doi.org/10.1016/S2221-1691(11)60121-4]
[26]
Saini, N.K.; Singha, M. Anti-inflammatory, analgesic and antipyretic activity of meth-anolic Tecomaria capensis leaves extract. Asian Pac. J. Trop., 2012, 870-874.
[27]
Autore, G.; Capasso, F.; De Fusco, R.; Fasulo, M.P.; Lembo, M.; Mascolo, N.; Menghini, A. Antipyretic and antibacterial actions of Teucrium polium (L.). Pharmacol. Res. Commun., 1984, 16(1), 21-29.
[http://dx.doi.org/10.1016/S0031-6989(84)80101-0] [PMID: 6608109]
[28]
Bafor, E.E.; Uwumarongie, H.O.; Idiake, J.O. Antipyretic effects of the aqueous, ethyl acetate and hexane leaf extracts of Ficus exasperata (Moraceae) in mice. J. Therm. Biol., 2010, 35, 275-279.
[http://dx.doi.org/10.1016/j.jtherbio.2010.05.011]
[29]
Asongalem, E.A.; Foyet, H.S.; Ekobo, S.; Dimo, T.; Kamtchouing, P. Antiinflammatory, lack of central analgesia and antipyretic properties of Acanthus montanus (Ness) T. Anderson. J. Ethnopharmacol., 2004, 95(1), 63-68.
[http://dx.doi.org/10.1016/j.jep.2004.06.014] [PMID: 15374608]
[30]
Venkataraman, S.; Baby, S.; Meera, R.; Devi, P. Anti-inflammatory, analgesic and Antipyretic activity of Pergularia daemia forsk. Int. J. Pharm. Biol. Sci. Arch., 2010, 1(4), 371-375.
[31]
Singh, N.; Gupta, A.K.; Juyal, V.; Chettri, R. Study of antipyretic activity of extracts of Bergenia ligulata wall. Int. J. Pharma Sci., 2010, 1(3), 1-5.
[32]
Bhaskar, V.H.; Balakrishnan, N. Analgesic, anti-inflammatory and antipyretic activities of Pergularia daemia and Carissa carandas. Daru, 2009, 17(3), 168-174.
[33]
Patra, A.; Jha, S.; Murthy, P.N.; Aher, V.D.; Chattopadhyay, P.; Panigrahi, G.; Roy, D. Anti-Inflammatory and antipyretic activities of Hygrophila spinosa T. Anders leaves (Acanthaceae). Trop. J. Pharm. Res., 2009, 8(2), 133-137.
[http://dx.doi.org/10.4314/tjpr.v8i2.44521]
[34]
Padhan, A.R.; Agrahari, A.K.; Meher, A. A Study on Antipyretic activity of Capparis zeylanica Linn. plant methanolic extract. Int. J. Pharm. Sci. Res., 2010, 1(3), 169-171.
[35]
Mittal, D.K.; Joshi, D.; Shukla, S. Antioxidant, antipyretic and choleretic activities of crude extract and active compound of Polygonum bistorta (Linn.) in albino rats. Int. J. Pharma Bio Sci., 2002, 2(1), 25-31.
[36]
Parhi, P.K.; Pattanayak, P.; Mishra, P.; Pani, M.K. An in-vivo study on analgesic and antipyretic activity of bark extracts of Gmelina arborea. Int. J. Pharm. Sci. Rev. Res., 2011, 10(2), 78-81.
[37]
Ekbote, T.; Maruthi, C.K.; Ramesh, M.; Riaz, B.S. Thippeswamy.; Veeresh, V. Evaluation of antipyretic activity of Azima tetracantha Lam. in rats. Indian J., 2010, 4(1), 19-22.
[38]
Khan, M.A.; Khan, H.; Khan, S.; Mahmood, T.; Khan, P.M.; Jabar, A. Anti-inflammatory, analgesic and antipyretic activities of Physalis minima Linn. J. Enzyme Inhib. Med. Chem., 2009, 24(3), 632-637.
[http://dx.doi.org/10.1080/14756360802321120] [PMID: 18825533]
[39]
Khan, M.D. Evaluation of analgesic and antipyretic activity of Marsilea trifolia Blanco. J. Sci. Eng. Res., 2011, 2(8), 1-3.
[40]
Trongsakul, S.; Panthong, A.; Kanjanapothi, D.; Taesotikul, T. The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz. J. Ethnopharmacol., 2003, 85(2-3), 221-225.
[http://dx.doi.org/10.1016/S0378-8741(03)00020-5] [PMID: 12639744]
[41]
Arul, V.; Miyazaki, S.; Dhananjayan, R. Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr. J. Ethnopharmacol., 2005, 96(1-2), 159-163.
[http://dx.doi.org/10.1016/j.jep.2004.09.013] [PMID: 15588665]
[42]
Mwonjoria, J.K.; Kariuki, H.K.; Waweru, F.N. The antinociceptive antipyretic effects of solanum incanum (Linneaus) in animal models. Phytomedicine, 2011, 2(1), 22-26.
[43]
Gupta, R.; Kumar, A.; Aiswarya, G.; Singh, J. Antipyretic activity of methanol extract of Acacia leucophloea Roxb bark. Int. J. Plan Env. Sci., 2011, 2(1), 138-140.
[44]
Niazi, J.; Gupta, V.; Chakarborty, P.; Kumar, P. Anti-inflammatory and antipyretic activity of Aleuritis moluccana leaves. Asian. J. Pharm. Clin. Res, 2011, 3(1), 35-37.
[45]
Enomfon, J.A.; Jude, E.O.; Idongesit, C.E. Antiplasmodial and antipyretic studies on root extracts of Anthocleista djalonensis against Plasmodium berghei. Asian Pac. J. Trop. Dis., 2012, 36-42.
[46]
Ahlawat, S.; Mishra, P.K.; Dalal, K.; Patra, A. Antipyretic activity of roots of Argyreia speciosa (burm. f.). Bojer. Int. J. Pharma Tech. Res., 2010, 2(4), 2165-2167.
[47]
Kumar, R.; Mishra, R. Analgesic and antipyretic activity of extracts of Asclepias currasavica Linn. Int. J. Pharm. Tech. Res., 2012, 4(1), 306-308.
[48]
Dey, A.; Shakar, A.A.M.; Rahman, S.M.A.; Amin Md, H.T. Evaluation of the Anti-inflammatory and antipyretic activities of the plant Boerhavia repens. (Family:Nyctaginaceae), JNPR, 2102M, 2(4), 471-474.
[49]
Hossain, E.; Mandal, S.C.; Gupta, J.K. Phytochemical screening and in-vivo antipyretic activity of the methanol leaf-extract of Bombax malabaricum DC (Bombacaceae). Trop. J. Pharm. Res., 2011, 10(1), 55-60.
[http://dx.doi.org/10.4314/tjpr.v10i1.66541]
[50]
Singh, A.; Manjul, P.C.; Gulzar, A.; Patel, R.; Datt, N. Antipyretic activity of Cassia fistula Linn. Pods. J. Nat. Prod., 2012, 2(3), 385-388.
[51]
Hallala, A.; Benalia, S.; Markouk, M.; Bekkouchea, K.; Larhsinia, M.; Chatib, A.; Romanec, A.; Abbada, A.; El Abdounid, M.K. Evaluation of the analgesic and antipyretic activities of Chenopodium ambrosioides L. Asian J. Exp. Biol. Sci., 2010, 1(4), 894-897.
[52]
Tag, H.; Namsa, N.D.; Mandal, M.; Kalita, P.; Das, A.K.; Mandal, S.C. Antipyretic and antibacterial activity of Chloranthus erectus (Buch.-Ham.) Verdcourt leaf extract: A popular folk medicine of Arunachal Pradesh. Indian J. Pharmacol., 2010, 42(5), 273-276.
[http://dx.doi.org/10.4103/0253-7613.70083] [PMID: 21206616]
[53]
Owoyele, O.S.O.; Dare, K.; Ogunbiyi, B.O.; Aruboula, E.A.; Soladoye, A.O. Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata. J. Med. Plants Res., 2008, 2(9), 219-225.
[54]
Vijay, P.; Vijayvergia, R. Analgesic, anti-inflammatory and antipyretic activity of Cissus quadrangularis. PDA J. Pharm. Sci. Technol., 2010, 2(1), 111-118.
[55]
Yesilada, E.; Küpeli, E. Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects. J. Ethnopharmacol., 2007, 110(3), 504-515.
[http://dx.doi.org/10.1016/j.jep.2006.10.016] [PMID: 17118593]
[56]
Binny, K.; Kumar, S.G.; Dennis, T. Anti-inflammatory and antipyretic properties of the rhizome of Costus speciosus (koen.) sm. J. Basic Clin. Pharm., 2010, 1(3), 177-181.
[PMID: 24825984]
[57]
Salawu, O.A.; Chindo, B.A.; Tijani, A.Y.; Adzu, B. Analgesic, anti-inflammatory, antipyretic and antiplasmodial effects of the methanolic extract of Crossopteryx febrifuga. J. Med. Plants Res., 2008, 2(8), 213-218.
[58]
Neha, S.; Ranvir, G.D.; Jangade, C.R. Analgesic and antipyretic activities of Curcuma longa rhizome extracts in Wister Rats. Vet. World, 2009, 2(8), 304-306.
[59]
Zakaria, Z.A.; Ghani, Z.D.; Nor, R.N.; Gopalan, H.K.; Sulaiman, M.R.; Jais, A.M.; Somchit, M.N.; Kader, A.A.; Ripin, J. Antinociceptive, anti-inflammatory, and antipyretic properties of an aqueous extract of Dicranopteris linearis leaves in experimental animal models. J. Nat. Med., 2008, 62(2), 179-187.
[http://dx.doi.org/10.1007/s11418-007-0224-x] [PMID: 18404320]
[60]
Yadav, S.; Kulshreshtha, M.; Goswami, M.; Rao, C.V.; Sharma, V. Elucidation of analgesic and antipyretic activities of Ficus bengalensis linn. Leaves in rats. J. Appl. Pharm. Sci., 2011, 1(1), 38-41.
[61]
Adesokan, A.A.; Yakubu, M.T.; Owoyele, B.V.; Akanji, M.A.; Soladoye, A.O.; Lawal, O.K. Effect of administration of aqueous and ethanolic extracts of Enantia chlorantha stem bark on brewer’s yeast-induced pyresis in rats. Afr. J. Biochem. Res., 2008, 2(7), 165-169.
[62]
Okokon, J.E.; Nwafor, P.A.; Abia, G.O.; Bankhede, H.K. Antipyretic and antimalarial activities of crude leaf extract and fractions of Enicostema littorale; Asian Pac. J. Trop, 2012, pp. 442-447.
[63]
George, M.; Joseph, L. Antipyretic and antidiarrheal activity of Geranium ocellatum leaves extract. World. Res. J. Med. Aromat. Plant, 2012, 1(2), 27-29.
[64]
Mandal, S.; Upadhyay, N.; Sharma, I.; Rohit, S. A comparative antipyretic activity of the crude extracts of the aerial parts of Glycosmis pentaphylla and Bauhinia variegate. Recent Res. Sci. Tech., 2011, 3(7), 16-18.
[65]
Akuodor, G.C.; Idris-Usman, M.S.; Mbah, C.C.; Megwas, U.A. Studies on anti-ulcer, analgesic and antipyretic properties of the ethanolic leaf extract of Gongronema latifolium in rodents. Afr. J. Biotechnol., 2010, 9(5), 2316-2321.
[66]
Patra, J.S.; Murthy, P.N.; Aher, V.D. Anti-Inflammatory and antipyretic activities of Hygrophila spinosa T. Anders Leaves (Acanthaceae). Trop. J. Pharm. Res., 2009, 8(2), 133-137.
[http://dx.doi.org/10.4314/tjpr.v8i2.44521]
[67]
Naik, N.D.; Reddy, R.G.; Naadella, B.C.; Bastipati, S. A study on antipyretic activity of petroleum ether extract of Ipomoea eriocarpa whole plant. Int. J. Pharmacol. Screen. Meth., 2012, 2(2), 58-60.
[68]
Deepa, P.K.; Usha, P.T.A.; Chandrasekharan Nair, A.M.; Prasannakuma, K.T. Antipyretic activity of seeds from red and white type of lotus (Nelumbo nucifera) in albino rat. Vet. World, 2(6), 213-214.
[69]
Olorunfemi, O.J.; Nworah, D.C.; Egwurugwu, J.N.; Hart, V.O. Evaluation of anti-Inflammatory, analgesic and antipyretic effect of Mangifera indica leaf extract on fever-induced albino rats (Wistar). Br. J. Pharmacol., 2012, 3(2), 54-57.
[70]
Sajeesh, T.; Arunachalam, K.; Parimelazhagan, T. Antioxidant and antipyretic studies on Pothos scandens L. Asian. Pac. J. Trop., 2011, 889-899.
[71]
Godhwani, S.; Godhwani, J.L.; Vyas, D.S. Ocimum sanctum: An experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals. J. Ethnopharmacol., 1987, 21(2), 153-163.
[http://dx.doi.org/10.1016/0378-8741(87)90125-5] [PMID: 3501819]
[72]
Backhouse, C.N.; Delporte, C.L.; Negrete, R.E.; Erazo, S.; Zuñiga, A.; Pinto, A.; Cassels, B.K. Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities. J. Ethnopharmacol., 2001, 78(1), 27-31.
[http://dx.doi.org/10.1016/S0378-8741(01)00309-9] [PMID: 11585684]
[73]
Devi, B.P.; Boominathan, R.; Mandal, S.C. Evaluation of antipyretic potential of Cleome viscosa Linn. (Capparidaceae) extract in rats. J. Ethnopharmacol., 2003, 87(1), 11-13.
[http://dx.doi.org/10.1016/S0378-8741(03)00099-0] [PMID: 12787948]
[74]
Valarmathi, R.; Rajendran, A.; Akilandeswari, S.; Senthamarai, R. Study on antipyretic activity of Mollugo pentaphylla Linn in albino mice. Int. J. Pharma Tech. Res. Hg., 2010, 2(4), 2388-2390.
[75]
Jayabharathi, M.; Chitra, M. Evaluation of anti-inflammatory, analgesic and antipyretic activity of Moringa concanensis Nimmo. J. Chem. Pharm. Res., 2011, 3(2), 802-806.
[76]
Makonnen, E.; Debella, A.; Zerihun, L.; Abebe, D.; Teka, F. Antipyretic properties of the aqueous and ethanol extracts of the leaves of Ocimum suave and Ocimum lamiifolium in mice. J. Ethnopharmacol., 2003, 88(1), 85-91.
[http://dx.doi.org/10.1016/S0378-8741(03)00175-2] [PMID: 12902056]
[77]
Yam, M.F.; Ang, L.F.; Basir, R.; Salman, I.M.; Ameer, O.Z.; Asmawi, M.Z. Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. Inflammopharmacology, 2009, 17(1), 50-54.
[http://dx.doi.org/10.1007/s10787-008-8038-3] [PMID: 19127348]
[78]
Gyasi, E.B.; Woode, E.; Ainooson, G.K.; Obiri, D.D.; Ansah, C.; Duwejua, M.; Donkoh, A. Anti-Inflammatory and antipyretic effects of an ethanolic extract of Palisota hirsuta K. Schum roots. Afr. J. Pharm. Pharmacol., 2008, 2(9), 191-199.
[79]
Gupta, M.K.; Mruthunjaya, K.; Garg, S.K.; Kumawat, R.S.; Jain, D.A. Evaluation of analgesic, anti-inflammatory and antipyretic potential of Parkinsonia aculeata Linn. Leaves. Int. J. Res. Pharm. Sci., 2011, 1(1), 100-109.
[80]
Singh, N.; Khatri, P.; Samantha, K.C. Antipyretic activity of extract of leaves of Quisqualis indica. Linn. Int. J. Pharm. Res. Dev., 2010, 2, 9.
[81]
Jude, E. Okokon.; Ndehekedehe, L.; Enomfon, J.A. In-vivo antiplasmodial and antipyretic activities of Smilax krausiana. Phytopharmacol., 2012, 3(2), 376-385.
[82]
Vilela, F.C.; Bitencourt, A.D.; Cabral, L.D.; Franqui, L.S.; Soncini, R.; Giusti-Paiva, A. Anti-inflammatory and antipyretic effects of Sonchus oleraceus in rats. J. Ethnopharmacol., 2010, 127(3), 737-741.
[http://dx.doi.org/10.1016/j.jep.2009.11.030] [PMID: 19962434]
[83]
Sharma, P.; Samanta, K.C.; Rathore, K.S. Antipyretic activity of methanolic extract of root of Tectona grandis Linn. on albino rats. J. Pharmacol. Toxicol., 2011, 1(2), 28-33.
[84]
Muhammad, N.; Saeed, M.; Khan, H. Antipyretic, analgesic and anti-inflammatory activity of Viola betonicifolia whole plant. BMC Complement. Altern. Med., 2012, 12, 59.
[http://dx.doi.org/10.1186/1472-6882-12-59] [PMID: 22551220]
[85]
Murthy, J.R.; Venkataraman, S.; Meera, R.; Kiran, S. Phytochemical investigation and Antipyretic activity of leaf extract of Vitex negundo. Linn. Int. J. Pharm. Tech. Res., 2010, 2(2), 1068-1073.
[86]
Shuklal, A.K.; Mishra, S.P.; Varma, R. Anti-inflammatory, analgesic and antipyretic activities of root of Wattakaka volubilis. Int. J. Pharm. Tech. Res., 2011, 3(3), 1334-1338.
[87]
Singh, A.P.; Fartyal, S.; Vajpayee, A.; Bora, K.S. Antipyretic and central nervous system activity of the roots of Zanthoxylum armatum, J. Pharma. Res Opin., 2011, 1(7), 181-184.
[88]
Senthilkumar, R.; Deivanai, D.; Iniyavan, M.; Parimelazhagan, T. Evaluation of in vitro Antioxidant and antipyretic activity of Zehneria maysorensis (W & A) Arn. leaf extracts. Asian Pac. J. Trop. Biomed., 2012, 1-6.
[89]
Khan, A.; Rahman, M.; Islam, S. Antipyretic activity of Peperomia pellucida leaves in rabbits. Turkish J. Biol., 2008, l32, 37-41.
[90]
Debell, A.; Makonnen, E.; Zerihun, L.; Abebe, D.; Teka, F. In-vivo antipyretic studies of the aqueous and ethanol extracts of the leaves of Ajuga remota and Lippia adoensis. Ethiop. Med. J., 2005, 43(2), 111-118.
[PMID: 16370541]

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy