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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

General Review Article

Apoptosis: Mediator Molecules, Interplay with Other Cell Death Processes and Therapeutic Potentials

Author(s): Jiban Barman, Ritesh Kumar, Gundappa Saha, Kartikeya Tiwari and Vikash K. Dubey*

Volume 19 , Issue 8 , 2018

Page: [644 - 663] Pages: 20

DOI: 10.2174/1389201019666180821093239

Price: $65

Abstract

Apoptosis, a form of programmed cell death, plays a very crucial role in various physiological processes for maintaining cell homeostasis. This process has several characteristic features like membrane blebbing, nuclear condensation, DNA fragmentation and cell shrinkage. Any defect in this highly regulated process eventually leads to extended cell survival and could result in neoplastic cell expansion followed by genetic instability. The apoptotic machinery is mainly processed and regulated by various caspases, a family of cysteine proteases. Significant advancement has been made towards understanding the molecular mechanisms of apoptosis which provides new insights in modulating the life or death of a cell. The main goal of this review is to highlight recent updates on apoptosis, the cross-talk with other cellular death processes and its therapeutic potentials.

Keywords: Apoptosis, proteases, autophagy, anoikis, senescence, drug target.

Graphical Abstract

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