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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Research Article

Catalyst Free and Energy Economical Synthesis of Thiazole Derivatives Bearing Azo Imine Linkage with Imidazole as Antimicrobial Agents

Author(s): Nayan M. Panchani and Hitendra S. Joshi*

Volume 16 , Issue 3 , 2019

Page: [284 - 290] Pages: 7

DOI: 10.2174/1570180815666180627155443

Price: $65


Background: Several strategies have been reported for the synthesis of thiazole derivatives.

Methods: However, many of these methods suffer from several drawbacks. Several modifications have been made to counter these problems. Here, we have synthesized a new series of 2-(2-((1HImidazol- 4-yl)methylene)hydrazinyl)-4-(4-substitutedphenyl)thiazoles without using the catalyst at room temperature.

Results: The structures of synthesized compounds have been confirmed by spectral analysis, such as Mass, IR, 1H NMR and 13C NMR. All synthesized compounds were screened for in vitro antibacterial activity against some gram-positive and gram-negative bacteria.

Conclusion: The thiazole derivatives, with a pharmacologically potent group, discussed in this article may provide valued therapeutic important in the treatment of microbial diseases, especially against bacterial and fungal infections.

Keywords: Thiazole, imidazole, thiosemicarbazide, catalyst, phenacyl bromide, methanol.

Graphical Abstract
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