Abstract
Cytokines are major controller of HIV replication and represent, at the same time, a target for viral-induced immune dysregulation. This mutual relationship has profound implications for both active HIV replication and immune-mediated governance of latency, in addition, cytokines have therapeutic value in the perspective of immune reconstitution. In the current article we will review the most relevant aspects emerged in almost 20 years of research in this area with particular reference to the distinct, but interconnected contribution of the most simple (cell lines) to the most complex (animal) models of HIV infection.
Keywords: Cytokine Network, HIV Infection, IMMUNOTHERAPY
Current Molecular Medicine
Title: The Cytokine Network in HIV Infection
Volume: 2 Issue: 8
Author(s): M. Alfano and G. Poli
Affiliation:
Keywords: Cytokine Network, HIV Infection, IMMUNOTHERAPY
Abstract: Cytokines are major controller of HIV replication and represent, at the same time, a target for viral-induced immune dysregulation. This mutual relationship has profound implications for both active HIV replication and immune-mediated governance of latency, in addition, cytokines have therapeutic value in the perspective of immune reconstitution. In the current article we will review the most relevant aspects emerged in almost 20 years of research in this area with particular reference to the distinct, but interconnected contribution of the most simple (cell lines) to the most complex (animal) models of HIV infection.
Export Options
About this article
Cite this article as:
Alfano M. and Poli G., The Cytokine Network in HIV Infection, Current Molecular Medicine 2002; 2 (8) . https://dx.doi.org/10.2174/1566524023361925
DOI https://dx.doi.org/10.2174/1566524023361925 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
Call for Papers in Thematic Issues
Molecular and Cellular Mechanisms in Vertigo / Vestibular Disorders
Vertigo and vestibular diseases are common among middle-aged and older adults, significantly increasing the risk of falls and leading to injuries and disabilities. Despite their prevalence, therapeutic advancements are hindered by a limited understanding of the underlying molecular and cellular mechanisms. This Special Issue is dedicated to bridging this gap ...read more
Related Journals

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Therapeutic Efficacy of Polyherbal Formulation Kabasura kudineer
Against Common Viral Fevers - A Perspective Review
Anti-Infective Agents Epstein-Barr Encephalitis in a Child with Congenital Human Immunodeficiency Virus Infection: A Case Report Calling for No Forgetfulness
Current HIV Research Novel and Viable Acetylcholinesterase Target Site for Developing Effective and Environmentally Safe Insecticides
Current Drug Targets Therapeutic Nucleic Acids
Recent Patents on Regenerative Medicine HIV-1, HCV and Alcohol in the CNS: Potential Interactions and Effects on Neuroinflammation
Current HIV Research Current Perspectives on Rabies Postexposure Prophylaxis
Infectious Disorders - Drug Targets FMRI of the Emotions: Towards an Improved Understanding of Amygdala Function
Current Medical Imaging Current Progress in the Development of HIV Vaccines
Current Pharmaceutical Design Autoimmune Diseases and Atherosclerosis: The Inflammatory Connection
Current Immunology Reviews (Discontinued) Biology of Mesenchymal Stem Cells
Current Rheumatology Reviews Development of HIV Reservoir Targeted Long Acting Nanoformulated Antiretroviral Therapies
Current Medicinal Chemistry The Role of Microglial Cells on Neuroinflammation: Possible Therapeutic Applications
Recent Patents on Regenerative Medicine Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents
Current Medicinal Chemistry AMPA Receptor Antagonists: Potential Therapeutic Applications
Recent Patents on CNS Drug Discovery (Discontinued) Primary Sjögren’s Syndrome Presenting with Rapidly Progressive Dementia: A Case Report
Current Alzheimer Research A Critical Analysis of New Molecular Targets and Strategies for Drug Developments in Alzheimers Disease
Current Drug Targets Effects of Vitamin A Deficiency and Opioids on Parvalbumin + Interneurons in the Hippocampus of the HIV-1 Transgenic Rat
Current HIV Research Drug Development Against Sleeping Sickness: Old Wine in New Bottles?
Current Medicinal Chemistry Conventional (Continuous) EEG Monitoring in the NICU
Current Pediatric Reviews The Gut Mucosa as a Site for Induction of Regulatory T-Cells
Current Pharmaceutical Design