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Current Diabetes Reviews


ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Factors Influencing the Hemodynamic and Metabolic Effects of Insulin in Muscle

Author(s): Stephen Rattigan, Lei Zhang, Hema Mahajan, Cathryn M. Kolka, Stephen M. Richards and Michael G. Clark

Volume 2 , Issue 1 , 2006

Page: [61 - 70] Pages: 10

DOI: 10.2174/157339906775473653

Price: $65


Insulin mediates its own access and that of glucose to muscle by capillary recruitment and an increase in bulk blood flow. In addition, insulin resistance of muscle may result in part from an impaired hemodynamic action of insulin. The present review examines some of the factors that influence the effects of insulin both at the level of hemodynamics and metabolism in muscle. Factors include fatty acids, the inflammatory cytokine TNFα , vasodilators that relax the blood vessels and increase bulk flow, and elevated blood pressure that may be mediated by endothelin, a potent locally released vasoconstrictor, or other vasoconstrictor influences.

Keywords: Capillary recruitment, Insulin action, Blood flow, Skeletal muscle, Microvascular

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