Abstract
Background: Cerebrovascular disease caused by atherosclerosis affecting cerebral and pre-cerebral arteries is one of the leading causes of morbidity and mortality in high-income countries. Medications of botanical origin are often characterized by good tolerability and are suitable for long-term treatment. Therefore, phytotherapy provides an interesting possibility for developing new therapies for the prevention of atherosclerosis and its complications that could be used at preclinical stages of the disease.
Objective: We reviewed the current literature studying the potential of various plant-based medications for prevention and treatment of early cerebral ischemia induced by atherosclerosis.
Methods: Literature search was performed in PubMed, Scopus, and Cochrane library to find trials on phytotherapy in cerebrovascular prevention and treatment.
Results: The present review covers the recent data on the prevention of cerebral ischemia with natural preparations and demonstrates the effect of anti-atherosclerotic therapy on the dynamics of minor neurological changes.
Conclusion: Phytotherapy appears to have a great potential for cerebrovascular disease prevention, combining good safety profiles with pleiotropic effects on different mechanisms atherosclerosis-related cerebral ischemia development.
Keywords: Cerebrovascular disease, cerebral ischemia, phytotherapy, natural preparation, carotid IMT, atherosclerosis.
Current Drug Metabolism
Title:Phytotherapy for the Prevention of Atherosclerosis-Associated Early Cerebral Ischemia
Volume: 19 Issue: 5
Author(s): Tatiana V. Kirichenko*, Veronika A. Myasoedova, Igor A. Sobenin and Alexander N. Orekhov
Affiliation:
- Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow,Russian Federation
Keywords: Cerebrovascular disease, cerebral ischemia, phytotherapy, natural preparation, carotid IMT, atherosclerosis.
Abstract: Background: Cerebrovascular disease caused by atherosclerosis affecting cerebral and pre-cerebral arteries is one of the leading causes of morbidity and mortality in high-income countries. Medications of botanical origin are often characterized by good tolerability and are suitable for long-term treatment. Therefore, phytotherapy provides an interesting possibility for developing new therapies for the prevention of atherosclerosis and its complications that could be used at preclinical stages of the disease.
Objective: We reviewed the current literature studying the potential of various plant-based medications for prevention and treatment of early cerebral ischemia induced by atherosclerosis.
Methods: Literature search was performed in PubMed, Scopus, and Cochrane library to find trials on phytotherapy in cerebrovascular prevention and treatment.
Results: The present review covers the recent data on the prevention of cerebral ischemia with natural preparations and demonstrates the effect of anti-atherosclerotic therapy on the dynamics of minor neurological changes.
Conclusion: Phytotherapy appears to have a great potential for cerebrovascular disease prevention, combining good safety profiles with pleiotropic effects on different mechanisms atherosclerosis-related cerebral ischemia development.
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Cite this article as:
Kirichenko V. Tatiana*, Myasoedova A. Veronika, Sobenin A. Igor and Orekhov N. Alexander, Phytotherapy for the Prevention of Atherosclerosis-Associated Early Cerebral Ischemia, Current Drug Metabolism 2018; 19 (5) . https://dx.doi.org/10.2174/1389200219666180305151601
DOI https://dx.doi.org/10.2174/1389200219666180305151601 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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