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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine

Author(s): Lauren Breithaupt, Christopher Hubel and Cynthia M. Bulik*

Volume 16 , Issue 8 , 2018

Page: [1102 - 1110] Pages: 9

DOI: 10.2174/1570159X16666180222163450

Price: $65


Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention in eating disorders.

Keywords: Eating disorders, genetics, GWAS, heterogeneity, anorexia nervosa, polygenic risk score, heritability, pathways.

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