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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Research Article

Caffeine Effect on HIFs/VEGF Pathway in Human Glioblastoma Cells Exposed to Hypoxia

Author(s): Grazia Maugeri, Agata G. D'Amico, Daniela M. Rasà, Salvatore Saccone, Concetta Federico, Gaetano Magro, Sebastiano Cavallaro and Velia D'Agata*

Volume 18 , Issue 10 , 2018

Page: [1432 - 1439] Pages: 8

DOI: 10.2174/1871520618666180209151750

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Abstract

Background: Caffeine represents the most used psychoactive drug in the world acting through different mechanisms of action and on several molecular targets. It exerts an anti-cancer role in glioblastoma multiforme (GBM). This neoplasia is characterized by extensive hypoxic foci triggering hypoxia-inducible factors (HIFs) expression. Among these factors, HIF-1α performs a crucial role in the induction of vascular endothelium growth factor (VEGF), a key player in angiogenesis and cell migration.

Methods: In this work, we have investigated whether caffeine counteracts GBM progression by modulating hypoxic event. Moreover, we analyzed the activation of phosphoinositide three kinase (PI3K)/Akt and mammalian mitogen activated protein kinase/Erk kinase (MAPK/ERK) signaling cascades.

Results: Our results have indicated that this psychostimulant drug significantly reduced HIF-1α and VEGF expression in GBM cells exposed to hypoxia. This effect is mediated through inhibition of PI3K/Akt and MAPK/ERK signaling pathways both implied in HIFs regulation.

Conclusion: The present data give new insight into antitumor activity of caffeine during GBM progression.

Keywords: Caffeine, glioblastoma multiforme, hypoxia-inducible factors, vascular endothelium growth factor, PI3K/Akt, MAPK/ERK.

Graphical Abstract

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