Abstract
Individuals with elevated homocysteine levels are at increased risk for cardiovascular disease and stroke, and neurodegenerative disorders such as Alzheimers and Parkinsons diseases Homocysteine is a modified form of the amino acid methionine that is tightly regulated by enzymes requiring folate. By impairing DNA repair mechanisms and inducing oxidative stress, homocysteine can cause the dysfunction or death of cells in the cardiovascular and nervous systems. Dietary folate stimulates homocysteine removal and may thereby protect cells against disease processes. The enzymes involved in homocysteine and folate metabolism provide novel targets for drug discovery.
Keywords: apoptosis, atherosclerosis, dietary folic acid, schizophrenia, stem cells
Current Medicinal Chemistry
Title: Folate and Homocysteine Metabolism: Therapeutic Targets in Cardiovascular and Neurodegenerative Disorders
Volume: 10 Issue: 19
Author(s): Mark P. Mattson and Frank Haberman
Affiliation:
Keywords: apoptosis, atherosclerosis, dietary folic acid, schizophrenia, stem cells
Abstract: Individuals with elevated homocysteine levels are at increased risk for cardiovascular disease and stroke, and neurodegenerative disorders such as Alzheimers and Parkinsons diseases Homocysteine is a modified form of the amino acid methionine that is tightly regulated by enzymes requiring folate. By impairing DNA repair mechanisms and inducing oxidative stress, homocysteine can cause the dysfunction or death of cells in the cardiovascular and nervous systems. Dietary folate stimulates homocysteine removal and may thereby protect cells against disease processes. The enzymes involved in homocysteine and folate metabolism provide novel targets for drug discovery.
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Cite this article as:
Mattson P. Mark and Haberman Frank, Folate and Homocysteine Metabolism: Therapeutic Targets in Cardiovascular and Neurodegenerative Disorders, Current Medicinal Chemistry 2003; 10 (19) . https://dx.doi.org/10.2174/0929867033456864
DOI https://dx.doi.org/10.2174/0929867033456864 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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