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Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Review Article

Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects

Author(s): Dominik Szwajgier*, Ewa Baranowska-Wojcik and Kamila Borowiec

Volume 15 , Issue 6 , 2018

Page: [531 - 543] Pages: 13

DOI: 10.2174/1567205014666171128102557

Price: $65

Abstract

Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.

Keywords: Alzheimer's disease, amyloid β-peptide, cinnamic acid, benzoic acid, acetylcholinesterase, butyrylcholinesterase, cognition.


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