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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

NF-κB Activating Scaffold Proteins as Signaling Molecules and Putative Therapeutic Targets

Author(s): Alain Chariot, Marie-Alice Meuwis, Marianne Bonif, Antonio Leonardi, Marie-Paule Merville, Jacques Gielen, Jacques Piette, Ulrich Siebenlist and Vincent Bours

Volume 10 , Issue 7 , 2003

Page: [593 - 602] Pages: 10

DOI: 10.2174/0929867033457926

Price: $65


Activation of transcription factors such as NF-κB occurs through signaling pathways involving sequential phosphorylation of a variety of substrates by distinct kinases. Proper assemby and activation of these kinases require interaction with non-enzymatic and essential partners named scaffold proteins. Here, we describe how the NF-κB activating scaffold proteins involved in the signaling pathways triggered by the proinflammatory cytokines TNFα, IL-1β and by the CD40 ligand play such roles. We also illustrate the human genetic diseases that are linked to mutations affecting genes coding for these proteins. We suggest that these scaffold proteins may be specifically targeted by novel therapeutical agents for the treatment of inflammation or cancers.

Keywords: scaffold proteins, ikk, nemo/ikk, genetic diseases, cancer, inflammation

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