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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Review Article

A Review on Defects of Dendritic Cells in Common Variable Immunodeficiency

Author(s): Laleh Sharifi, Naeimeh Tavakolinia, Fatemeh Kiaee, Nima Rezaei, Monireh Mohsenzadegan, Gholamreza Azizi, Reza Yazdani, Mansoureh Shariat, Abbas Mirshafiey* and Asghar Aghamohammadi*

Volume 17 , Issue 2 , 2017

Page: [100 - 113] Pages: 14

DOI: 10.2174/1871530317666170613125009

Price: $65

Abstract

Background and Objectives: Common variable immunodeficiency (CVID) is the most important primary disorder that is associated with clinical complications including recurrent infections, malignancy and autoimmune diseases. The genetic cause of CVID is mostly unknown and only a few genetic causes are identified. The various options are proposed for determining the etiology of CVID patients, such as T- and B-cell defects, Toll-like receptors (TLRs) impairments, altered cytokine production as well as blemished dendritic cells (DCs). The patients with CVID show a reduction in number and frequency of DCs in blood, an altered expression of cell surface molecules, and defective activation through toll-like receptors (TLRs). Also loss of IFNα has a critical role in B-cell impairments of CVID patients. The aim of this review is to collect under one umbrella, all the recent knowledge about DCs defects of CVID patients.

Methods: This review covers basic information about physiology of DCs followed by reports of DCs situation in CVID.

Conclusion: According to the results of researches assessing DCs frequency and function in CVID, the roll of DCs in the pathogenesis of CVID cannot be ruled out. The article is expected to encourage the researchers to do comprehensive researches about complex connections between DCs and other immune cells in CVID.

Keywords: Common variable immunodeficiency, dendritic cells, B-cell, T-cell, toll-like receptors, cytokines.

Graphical Abstract

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