PPARs in Neurodegenerative and Neuroinflammatory Pathways

Title:PPARs in Neurodegenerative and Neuroinflammatory Pathways

Volume: 15 Issue: 4

Author(s): E. Benedetti, L. Cristiano, A. Antonosante, M. d'Angelo, B. d'Angelo, S. Selli, V. Castelli, R. Ippoliti, A. Giordano and A. Cimini*

Affiliation:

• National Institute for Nuclear Physics (INFN), Gran Sasso National Laboratory (LNGS), Assergi,Italy

Keywords: Neurodegenetic disease, immune system, microglia cells, cytokines, neuroinflammation, neurons.

Abstract: Background: PPARs are lipid sensors activated by dietary lipids or their metabolites, mainly fatty acids and eicosanoids, that play critical roles in CNS biology, since brain has a very high lipid content and has the higher energetic metabolism in the body.

Methods: In neurodegenerative diseases in addition to metabolic impairment, also neuroinflammation is observed and PPARs are also closely linked to inflammatory processes. Several studies have revealed a complicated relationship between the innate immune response and tissue metabolism.

Results: In the brain, during pathological conditions, an alteration in metabolic status occurs, particularly involving glucose utilization and production, a condition which is generally related to metabolic changes.

Conclusion: Taking into account the high expression of PPARs in the brain, this review will focus on the role of these transcription factors in CNS diseases.

Cite this article as:

Benedetti E., Cristiano L., Antonosante A. , d'Angelo M. , d'Angelo B. , Selli S. , Castelli V. , Ippoliti R., Giordano A. and Cimini A. *, PPARs in Neurodegenerative and Neuroinflammatory Pathways, Current Alzheimer Research 2018; 15 (4) . https://dx.doi.org/10.2174/1567205014666170517150037