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Current Signal Transduction Therapy


ISSN (Print): 1574-3624
ISSN (Online): 2212-389X

Review Article

A New Approach for Skin-Derived Precursors to Ameliorate Skin Photodamage Through Activation of Nrf2 Signaling Pathway

Author(s): Dehai Xian, Jianqiao Zhong* and Xiaoqing Gao

Volume 12 , Issue 1 , 2017

Page: [34 - 38] Pages: 5

DOI: 10.2174/1574362412666170206163620

Price: $65


Background: Skin photodamage exhibits poorly clinical efficacy and so far has rarely satisfactory treatments. Ultraviolet (UV)-induced overproduction of reactive oxygen species (ROS), NF-E2-related factor 2 (Nrf2) inactivation and Nrf2/antioxidant response elements (ARE) signaling pathway blockage play important roles in skin photodamage pathogenesis. Skin-derived precursor cells (SKPs), a population of dermal stem cells, are predominant over wound repair and skin regeneration.

Objective: To hypothesize that SKPs are useful in skin photodamage by Nrf2 activation.

Methods: Published papers on skin photodamage and SKPs were collected and reviewed. Besides, the findings from our preliminary experiment were reported in this article.

Results: It has been confirmed that stem cells could participate in tissue repair via activating Nrf2 and Nrf2/ARE signal transduction pathway. Furthermore, our previous and current outcomes revealed that SKPs could ameliorate UVB-induced apoptosis or damage and significantly up-regulate Nrf2 expression after UV irradiation.

Conclusion: Together the above data, we speculate that SKPs may be good candidates for control of skin photodamage through activating Nrf2 and its signaling pathway. These would provide a new approach for resisting skin photodamage.

Keywords: Skin photodamage, skin-derived precursor cells (SKPs), NF-E2-related factor 2 (Nrf2), reactive oxygen species (ROS), ultraviolet (UV), oxidative stress, stem cells.

Graphical Abstract

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